{"id":"W4297519721","doi":"10.1101/2022.09.27.509701","title":"The human MRS2 magnesium binding domain is a regulatory feedback switch for channel activity","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Magnesium in Health and Disease","field":"Nursing","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Congressionally Directed Medical Research Programs; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Defense","keywords":"Mutant; Cell biology; Chemistry; Biochemistry; HEK 293 cells; RNA-binding protein; Biology; Biophysics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087785,0.0002570635,0.0002005218,0.00009348558,0.0001609459,0.0002362583,0.0001827356,0.0003185782,0.003034446],"category_scores_gemma":[0.0001672376,0.0001378397,0.0002044028,0.00008160488,0.0002239591,0.00009614889,0.0001571236,0.0002920303,0.001278783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002496768,"about_ca_system_score_gemma":0.0001796687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005533511,"about_ca_topic_score_gemma":0.0005882358,"domain_scores_codex":[0.9998763,0.0000205409,0.00001039883,0.00003652952,0.0000355813,0.00002063575],"domain_scores_gemma":[0.999897,0.00002379708,0.0000268163,0.00001385404,0.00001137062,0.00002716344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001405793,0.000008296474,0.0002903136,0.00001198255,0.000002283888,0.0001110305,0.000006686678,0.00005219267,0.9982455,0.0001146677,0.0001091948,0.0009074689],"study_design_scores_gemma":[0.00003384619,0.00009128802,0.006970858,0.000005121514,0.000006457157,0.0008469782,0.00002320593,0.001812789,0.9848531,0.0001155809,0.005231874,0.000008884054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916891,0.000545146,0.004906462,0.0002157601,0.00006914909,0.0000177382,0.0005739491,0.000263673,0.001718964],"genre_scores_gemma":[0.9950864,0.00008337028,0.002230535,0.00007304262,0.00001329836,0.00001071657,0.0005109604,0.00003538118,0.001956387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003034446,"threshold_uncertainty_score":0.01015121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02151920364487624,"score_gpt":0.2659685794567399,"score_spread":0.2444493758118637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}