{"id":"W4297521041","doi":"10.1101/2022.09.27.509806","title":"Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Providence Health Care Research Institute","funders":"Rijksuniversiteit Groningen; Universitair Medisch Centrum Groningen; European Commission","keywords":"Senescence; CTGF; Decorin; Fibrosis; Idiopathic pulmonary fibrosis; Growth factor; Transforming growth factor; Pulmonary fibrosis; Connective tissue; Cell biology; Chemistry; Lung; Extracellular matrix; Pathology; Cancer research; Receptor; Biology; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001935412,0.0002629744,0.0001769935,0.00009948184,0.00009325632,0.0002378318,0.00007277234,0.0002192538,0.0008279991],"category_scores_gemma":[0.0001336548,0.0001332366,0.000158676,0.00009870878,0.000125583,0.0001497713,0.0001784278,0.0002711968,0.000146326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001275256,"about_ca_system_score_gemma":0.00007367854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003717266,"about_ca_topic_score_gemma":0.0006478813,"domain_scores_codex":[0.9998562,0.00002816595,0.00002288742,0.00002717993,0.00003665354,0.00002876097],"domain_scores_gemma":[0.9998233,0.00007048535,0.00003966768,0.00001885454,0.00002263024,0.0000250997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004144719,0.0000162108,0.0001389265,0.00002496849,0.00000228415,0.00001793024,0.0000223308,0.00005463354,0.9993992,0.000007944469,0.000006675962,0.0002673967],"study_design_scores_gemma":[0.00001127007,0.0005904135,0.008080846,0.000008261511,0.00001453523,0.0001107956,0.00007643546,0.0007472712,0.9895003,0.00002294039,0.0008288741,0.000008047651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979141,0.0006603163,0.0007734168,0.00001753749,0.00001742009,0.00002056605,0.0001125736,0.00001138667,0.0004725875],"genre_scores_gemma":[0.9971808,0.0003757926,0.001256005,0.00002882697,0.000004166227,0.00003907504,0.000190602,0.000006357932,0.0009183791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008279991,"threshold_uncertainty_score":0.002769947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009336099105697288,"score_gpt":0.2389189376895221,"score_spread":0.2295828385838248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}