{"id":"W4297537451","doi":"10.1016/j.bpj.2022.09.034","title":"FO-F1 coupling and symmetry mismatch in ATP synthase resolved in every FO rotation step","year":2022,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Japan Science and Technology Agency; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"ATP synthase; Rotation (mathematics); Rotor (electric); Molecular machine; Symmetry (geometry); Protein subunit; Molecular motor; Rotary engine; Homogeneous space; ATPase; Coupling (piping); Crystallography; Physics; Chemistry; Biophysics; Enzyme; Biology; Nuclear magnetic resonance; Nanotechnology; Materials science; Mathematics; Biochemistry; Quantum mechanics; Geometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000357768,0.0001168117,0.0001611899,0.0001146794,0.00016029,0.00004667145,0.0001528042,0.00006654355,0.00003316134],"category_scores_gemma":[0.00008470984,0.0001151739,0.00007289146,0.0002128037,0.00005237426,0.00001004954,0.0002082274,0.0004324102,0.000003317338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006302258,"about_ca_system_score_gemma":0.00009474833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006893016,"about_ca_topic_score_gemma":0.00001557024,"domain_scores_codex":[0.9987954,0.0001073121,0.0002508172,0.0002596249,0.0002858751,0.0003008921],"domain_scores_gemma":[0.999592,0.00004847732,0.00007014179,0.0001369382,0.00003441547,0.0001180434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003604394,0.0002446328,0.007642408,0.000015754,0.00002044006,0.0001774817,0.00006597622,0.0003317547,0.9868282,0.00004096931,0.0002430022,0.004028935],"study_design_scores_gemma":[0.01151322,0.003512763,0.09409958,0.0003025887,0.00007091563,0.0004209214,0.005951653,0.07033134,0.7910988,0.0005752411,0.02038964,0.001733323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986403,0.0003524547,0.000436717,0.0002868116,0.0000744322,0.0001209353,0.00001451526,0.000003898427,0.00006993375],"genre_scores_gemma":[0.9991183,0.0001556421,0.0002121575,0.00009813733,0.0002636456,0.00002217773,0.00002746952,0.00001814396,0.00008429951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1957294,"threshold_uncertainty_score":0.4696656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01576619385141228,"score_gpt":0.2877479044487853,"score_spread":0.2719817105973731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}