{"id":"W4297541830","doi":"10.3389/fmicb.2022.980989","title":"Lacticaseibacillus rhamnosus R0011 secretome attenuates Salmonella enterica serovar Typhimurium secretome-induced intestinal epithelial cell monolayer damage and pro-inflammatory mediator production in intestinal epithelial cell and antigen-presenting cell co-cultures","year":2022,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lallemand (Canada); Ontario Tech University","funders":"Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Chemokine; Biology; Innate immune system; Cell biology; Immune system; Microbiology; Secretion; Proinflammatory cytokine; Salmonella enterica; Cytokine; Inflammation; Immunology; Salmonella; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770253,0.0003911939,0.0004728594,0.0001586687,0.00007680617,0.000281591,0.0001407382,0.0002379155,0.0008331081],"category_scores_gemma":[0.000146275,0.000115164,0.0002716672,0.0001173932,0.0001980172,0.0001493762,0.0002201258,0.0006102232,0.0002721385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001493272,"about_ca_system_score_gemma":0.0002675086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005033917,"about_ca_topic_score_gemma":0.000792359,"domain_scores_codex":[0.9998274,0.00003937097,0.00002111524,0.00001752623,0.00004341385,0.0000512096],"domain_scores_gemma":[0.9998313,0.00002974066,0.00004944942,0.00002012468,0.00001715559,0.00005212356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00030294,0.000073124,0.0000983628,0.00002885013,0.000002973184,0.00003109113,0.00001507777,0.00002888953,0.9989685,0.00001093679,0.00001328076,0.0004260279],"study_design_scores_gemma":[0.00002227006,0.001716993,0.004527074,0.000006387537,0.00001311135,0.00009286498,0.00006609563,0.0006359204,0.9923531,0.00001235664,0.000549913,0.000003866357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982452,0.0005521641,0.0005216455,0.00005645014,0.00002084222,0.00001495239,0.000159333,0.00003243535,0.0003968127],"genre_scores_gemma":[0.9970067,0.0004354629,0.000791134,0.00004387584,0.00001226802,0.00002151597,0.0003387045,0.000008484397,0.001341909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008331081,"threshold_uncertainty_score":0.002786994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009159491952558494,"score_gpt":0.2281700365938304,"score_spread":0.2190105446412719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}