{"id":"W4297541830","doi":"10.3389/fmicb.2022.980989","title":"Lacticaseibacillus rhamnosus R0011 secretome attenuates Salmonella enterica serovar Typhimurium secretome-induced intestinal epithelial cell monolayer damage and pro-inflammatory mediator production in intestinal epithelial cell and antigen-presenting cell co-cultures","year":2022,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lallemand (Canada); Ontario Tech University","funders":"Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Chemokine; Biology; Innate immune system; Cell biology; Immune system; Microbiology; Secretion; Proinflammatory cytokine; Salmonella enterica; Cytokine; Inflammation; Immunology; Salmonella; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009111186,0.0006512915,0.0008458556,0.0007543056,0.0005079053,0.00005722433,0.0004755854,0.0004722389,0.0003137477],"category_scores_gemma":[0.0002297091,0.0006609239,0.0001125476,0.0004108127,0.0005589177,0.0002304933,0.0006254968,0.001668775,0.00006277276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003022424,"about_ca_system_score_gemma":0.000199096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001586257,"about_ca_topic_score_gemma":0.00006437683,"domain_scores_codex":[0.9951563,0.001393601,0.001009145,0.001334501,0.0000906363,0.001015847],"domain_scores_gemma":[0.9984635,0.0002366314,0.0006039257,0.0004548322,0.0001367811,0.0001043493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007103733,0.0002935237,0.1097389,0.0001937335,0.00004426367,0.0001844685,0.00391275,0.00002712187,0.8812237,0.00000292136,0.003506859,0.0001613862],"study_design_scores_gemma":[0.003561675,0.0006091079,0.006102887,0.00005301518,0.00005557124,0.000766114,0.005325862,0.0001200033,0.9741336,0.00005134011,0.008432631,0.0007881951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926994,0.002087147,0.0001217765,0.0001929113,0.003140361,0.001179846,0.0003341647,0.0001147085,0.0001296722],"genre_scores_gemma":[0.9963815,0.0001503476,0.001535896,0.0001253551,0.0002124735,0.0001839313,0.0005189292,0.00007568661,0.0008158663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.103636,"threshold_uncertainty_score":0.9995842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009159491952558494,"score_gpt":0.2281700365938304,"score_spread":0.2190105446412719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}