{"id":"W4297790804","doi":"10.1101/2022.09.01.506223","title":"Intra-islet glucagon signalling regulates pulsatile insulin secretion and glucose homeostasis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research; Banting and Best Diabetes Centre, University of Toronto; Medical Research Council; Novo Nordisk; Diabetes UK; Wellcome Trust","keywords":"Glucagon receptor; Internal medicine; Endocrinology; Glucose homeostasis; Islet; Glucagon; Insulin; Calcium; Biology; Blood sugar regulation; Medicine; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286828,0.0003572282,0.0002840274,0.0002033886,0.0001090972,0.0005568381,0.0002724072,0.0002933381,0.002255474],"category_scores_gemma":[0.0001243292,0.0001578307,0.0001684988,0.0001479233,0.0003145855,0.00027697,0.0003394893,0.0005754747,0.0004520501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002189246,"about_ca_system_score_gemma":0.0001353088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001957436,"about_ca_topic_score_gemma":0.0002110218,"domain_scores_codex":[0.9998275,0.00002002433,0.00001138391,0.00005660014,0.00004508956,0.00003931975],"domain_scores_gemma":[0.9998406,0.00001420044,0.00005634937,0.00001622123,0.00001480484,0.00005773645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004317195,0.00002054612,0.0006776862,0.00002790259,0.000002515216,0.00004749886,0.00001057164,0.00002812621,0.9976726,0.0000370905,0.00003157544,0.001012262],"study_design_scores_gemma":[0.0001070328,0.0008214898,0.053539,0.00002791511,0.00006069583,0.0009805475,0.0001562192,0.00126776,0.9396274,0.0002113057,0.003180471,0.00002012311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943272,0.001745172,0.001961178,0.00009592747,0.00003753554,0.00001458901,0.0003942072,0.00008632036,0.001337752],"genre_scores_gemma":[0.9947232,0.0009953693,0.001735002,0.00005889583,0.00002409299,0.00004244782,0.0003073949,0.00005702732,0.002056586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002255474,"threshold_uncertainty_score":0.007545292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369070748441393,"score_gpt":0.2223827048553547,"score_spread":0.2086919973709408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}