{"id":"W4297805114","doi":"10.7554/elife.80813.sa2","title":"Author response: Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway","year":2022,"lang":"en","type":"peer-review","venue":"","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact","funders":"","keywords":"Hemoglobin; Plasmodium falciparum; Aminopeptidase; Digestion (alchemy); Biology; Computational biology; Chemistry; Biochemistry; Malaria; Chromatography; Immunology; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002782188,0.000921838,0.0005972591,0.0007272325,0.001175037,0.0018231,0.001290165,0.004186446,0.0828261],"category_scores_gemma":[0.01147837,0.0004536942,0.0007291217,0.000426997,0.0006562512,0.001003588,0.0009009173,0.003345507,0.02893348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001167283,"about_ca_system_score_gemma":0.002242496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00150476,"about_ca_topic_score_gemma":0.003219305,"domain_scores_codex":[0.9974306,0.0004305365,0.000189871,0.0003105619,0.001371051,0.0002673731],"domain_scores_gemma":[0.9917304,0.001749897,0.0003985311,0.0003260107,0.004894349,0.0009008961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001479522,0.00003233279,0.0001774232,0.0001059347,0.000007702421,0.000191254,0.00001806445,0.00005724687,0.001191825,0.0004185396,0.9892753,0.008376531],"study_design_scores_gemma":[0.0001165138,0.0001253568,0.0007040937,0.0001048375,0.00002136046,0.0002534068,0.0001449459,0.0003459685,0.005226944,0.0006288762,0.9922996,0.00002810008],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"commentary","genre_scores_codex":[0.004978873,0.003808418,0.006391641,0.2709718,0.6464718,0.0006361654,0.00357893,0.002019261,0.06114319],"genre_scores_gemma":[0.04518658,0.007962623,0.01122278,0.1679427,0.1397764,0.0005039669,0.005042701,0.001593972,0.6207682],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.0828261,"threshold_uncertainty_score":0.277081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02737862568352728,"score_gpt":0.3137891392654583,"score_spread":0.286410513581931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}