{"id":"W4297821452","doi":"10.1016/j.annonc.2022.07.1886","title":"1400P Efficacy and safety of 177Lu-PNT2002 prostate-specific membrane antigen (PSMA) therapy in metastatic castration resistant prostate cancer (mCRPC): Initial results from SPLASH","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; Université Laval; BC Cancer Agency; Princess Margaret Cancer Centre; McGill University; University Health Network","funders":"","keywords":"Medicine; Prostate cancer; Glutamate carboxypeptidase II; Oncology; Internal medicine; Prostate-specific antigen; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005757136,0.0005298611,0.0009339062,0.0003667073,0.0002389915,0.0006943409,0.0004811812,0.0004523193,0.001931161],"category_scores_gemma":[0.0005026023,0.0002411873,0.000573746,0.0003729704,0.0007750803,0.0007198804,0.0002461983,0.001340312,0.0004258687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001151825,"about_ca_system_score_gemma":0.0008507521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003123215,"about_ca_topic_score_gemma":0.002976619,"domain_scores_codex":[0.999783,0.0000817765,0.00000887317,0.00003316802,0.00004543234,0.00004785697],"domain_scores_gemma":[0.9998366,0.00005115677,0.00002638131,0.00002094101,0.00001294788,0.0000519708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2222365,0.0183959,0.008852073,0.0009671047,0.001115585,0.0005629968,0.0007300664,0.008671732,0.404622,0.001090064,0.002765046,0.329991],"study_design_scores_gemma":[0.04499767,0.5282411,0.09901477,0.0001176561,0.002019687,0.002911998,0.000433052,0.01342751,0.2905487,0.0008471602,0.01730671,0.0001340682],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951609,0.001779712,0.0003621214,0.0001385214,0.00001852621,0.00008199141,0.0002696146,0.0000509038,0.002137788],"genre_scores_gemma":[0.9958948,0.0009412728,0.0004159882,0.0001102419,0.00002740103,0.00004385149,0.0006122672,0.00005527816,0.001898936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003123215,"threshold_uncertainty_score":0.008357167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1391257395075549,"score_gpt":0.4154387542320526,"score_spread":0.2763130147244977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}