{"id":"W4297822131","doi":"10.1101/2022.09.05.506638","title":"NUDT6, the Antisense Protein of FGF2 Gene, Plays a Depressogenic Role by Promoting Inflammation and Suppressing Neurogenesis without Altering FGF2 Signaling","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hacettepe Üniversitesi; National University of Defense Technology; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Dalhousie University; L'Oreal USA","keywords":"Neurogenesis; Fibroblast growth factor; Protein kinase B; Proinflammatory cytokine; Hippocampal formation; Neuroscience; Biology; Cell biology; Signal transduction; Inflammation; Receptor; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279148,0.0003742222,0.0002066545,0.0001728578,0.0002118393,0.0002133177,0.0001670919,0.0003436659,0.001948609],"category_scores_gemma":[0.00009571273,0.0001211712,0.0002474944,0.0000932364,0.000241159,0.0001944778,0.0001600767,0.0004968122,0.0004174801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427595,"about_ca_system_score_gemma":0.0001860456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006228642,"about_ca_topic_score_gemma":0.001150087,"domain_scores_codex":[0.9999028,0.00001271611,0.00001012269,0.00002827524,0.00003369296,0.00001228011],"domain_scores_gemma":[0.9999442,0.000007435784,0.00001963014,0.000007071334,0.000006569463,0.00001508489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003159068,0.000006537621,0.00006019325,0.00002667811,0.000002297273,0.00001752927,0.00000445436,0.00002655604,0.998854,0.0001099016,0.00004837503,0.000811961],"study_design_scores_gemma":[0.00001839565,0.000125078,0.001134386,0.000005163251,0.000008729001,0.0002249166,0.000009847112,0.0005290097,0.9908246,0.0000624341,0.007052346,0.00000502702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9523425,0.006142156,0.03040385,0.0006338613,0.0003619088,0.00009912128,0.002060042,0.0006535632,0.007302917],"genre_scores_gemma":[0.9599326,0.002986837,0.02340772,0.0002637022,0.0000462367,0.0001377646,0.001974554,0.0001026208,0.01114801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001948609,"threshold_uncertainty_score":0.006518722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008802312929977645,"score_gpt":0.2227285152429006,"score_spread":0.2139262023129229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}