{"id":"W4297848983","doi":"10.1101/2022.09.07.507060","title":"Pre-existing immunity to influenza viruses through infection and/or vaccination leads to viral mutational signatures associated with unique immune responses during a subsequent infection","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Dalhousie University","funders":"Innovation Saskatchewan","keywords":"Virology; Immune system; Vaccination; Biology; Immunity; Original antigenic sin; Immunology; Virus; Antigenic drift; Viral shedding; Influenza A virus; Influenza vaccine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190137,0.0001319083,0.000148415,0.00014782,0.0001005064,0.0002355514,0.00007803331,0.0001836775,0.0009469187],"category_scores_gemma":[0.0001099596,0.0000894879,0.0001451975,0.00004843078,0.0001506426,0.0001274625,0.0001824936,0.000386987,0.0001846382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001306326,"about_ca_system_score_gemma":0.00007817459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001909062,"about_ca_topic_score_gemma":0.0003300602,"domain_scores_codex":[0.9999018,0.00001220275,0.000006550011,0.00002551976,0.000017012,0.00003685462],"domain_scores_gemma":[0.9999089,0.00001120021,0.00003094768,0.00001191147,0.00001059566,0.00002639719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001602699,0.00003754417,0.00899382,0.00001402915,0.000006159345,0.00006138466,0.00002236537,0.00004205385,0.9894667,0.00003837089,0.00002529229,0.001131973],"study_design_scores_gemma":[0.00001718685,0.002486308,0.5796843,0.00001986092,0.00004581317,0.002077446,0.0002642279,0.001541479,0.4115869,0.0001644931,0.002099217,0.00001272686],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991596,0.0001182828,0.0003052597,0.00001156474,0.000003182303,0.000004930649,0.00006886238,0.000007294786,0.0003210118],"genre_scores_gemma":[0.9990413,0.00006798778,0.0003392322,0.00002235877,0.000003286465,0.00000789065,0.0001388313,0.000003288139,0.000375886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009469187,"threshold_uncertainty_score":0.003167748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06450493356245542,"score_gpt":0.355026657073262,"score_spread":0.2905217235108066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}