{"id":"W4297849081","doi":"10.1101/2022.09.08.507176","title":"Potentiation of Adipogenesis by Reactive Oxygen Species is a Unifying Mechanism in the Pro-adipogenic Properties of Bisphenol A and its New Structural Analogues","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Alberta Children's Hospital; University of Calgary","funders":"University of Calgary","keywords":"Adipogenesis; Reactive oxygen species; Adipocyte; Cell biology; Adipose tissue; Chemistry; Mitochondrion; Bisphenol A; Oxidative stress; Bisphenol; Endocrinology; Biology; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001828275,0.0004333362,0.0001845231,0.0002950002,0.0001791535,0.000251617,0.0001611478,0.0002470905,0.001325099],"category_scores_gemma":[0.0001180206,0.0001580771,0.0003691155,0.0001617139,0.0002080981,0.0002470592,0.0003012811,0.000393987,0.0002292983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001755195,"about_ca_system_score_gemma":0.0001589521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002932076,"about_ca_topic_score_gemma":0.0003215132,"domain_scores_codex":[0.9998535,0.00003097868,0.000012272,0.00002977287,0.00004676155,0.00002673413],"domain_scores_gemma":[0.999861,0.00001565548,0.00005166085,0.0000138822,0.00003485338,0.0000230376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001517264,0.00001950186,0.0005186239,0.00008205407,0.00001356797,0.00006485856,0.00001792242,0.00009406074,0.9965275,0.0003316108,0.00002591453,0.002152725],"study_design_scores_gemma":[0.00001325809,0.0004744616,0.01413671,0.00002103361,0.00004865933,0.0002584107,0.00008592754,0.0005654601,0.978561,0.00056938,0.005254515,0.00001104416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713262,0.007145456,0.01716095,0.0004038605,0.0001343633,0.00005560403,0.0004770786,0.00009757918,0.003198989],"genre_scores_gemma":[0.9908584,0.003528653,0.002835793,0.0001381736,0.00003295814,0.00003615493,0.0003187126,0.00001594652,0.002235344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325099,"threshold_uncertainty_score":0.004432917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01821263249442924,"score_gpt":0.2484266013972073,"score_spread":0.2302139689027781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}