{"id":"W4297855199","doi":"10.1172/jci.insight.159590","title":"Cell-free DNA topology depends on its subcellular and cellular origins in cancer","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Temerty Faculty of Medicine, University of Toronto; University of Toronto; Canadian Institutes of Health Research; Hospital for Sick Children; Government of Ontario; Princess Margaret Cancer Foundation","keywords":"Liquid biopsy; Cell-free fetal DNA; Cancer; Cancer cell; Cancer research; Mitochondrion; Biology; Extracellular; Topology (electrical circuits); Membrane topology; Cell biology; Chemistry; Computational biology; Membrane protein; Biochemistry; Genetics; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001763179,0.0002296211,0.0001988367,0.0001243312,0.0001707576,0.0000193062,0.0004584232,0.0001425146,0.0004495941],"category_scores_gemma":[0.00004317353,0.0002481036,0.00007959956,0.0001807766,0.0000817677,0.000005757126,0.0005786811,0.0002904094,0.00001568801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001107766,"about_ca_system_score_gemma":0.0001323337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008606978,"about_ca_topic_score_gemma":0.00009838061,"domain_scores_codex":[0.9983277,0.0001928498,0.0002540527,0.0006076478,0.0002350146,0.0003827329],"domain_scores_gemma":[0.9990366,0.00002001335,0.00008904401,0.0006800118,0.00003022025,0.0001441216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001926745,0.0004201234,0.003976359,0.00003778349,0.00002568542,0.0003010977,0.0001626793,0.0003236494,0.9878808,0.001871947,0.004348071,0.0004591422],"study_design_scores_gemma":[0.001268014,0.0003934996,0.0004864026,0.0000051517,0.00002096767,0.00001134926,0.00008152278,0.000114389,0.7240415,0.0002158497,0.2730615,0.0002999236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795373,0.01409668,0.00004457224,0.0004251919,0.0004148499,0.000253246,0.00008652313,0.00001897255,0.005122627],"genre_scores_gemma":[0.9955783,0.0004008713,0.00007548877,0.0007641358,0.000203661,0.0001499697,0.0001283447,0.00004870511,0.0026505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2687134,"threshold_uncertainty_score":0.9999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482107334126428,"score_gpt":0.2558260965146194,"score_spread":0.2410050231733551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}