{"id":"W4297855249","doi":"10.4049/jimmunol.2200534","title":"Pre–Germinal Center Interactions with T Cells Are Natural Checkpoints to Limit Autoimmune B Cell Responses","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Multiple Sclerosis Society; Natural Sciences and Engineering Research Council of Canada; Multiple Sclerosis Society of Canada; Government of Canada","keywords":"Germinal center; CD40; Cell biology; Biology; B cell; Antigen; B-cell receptor; Antigen-presenting cell; Cytotoxic T cell; T cell; Immune system; Immunology; Antibody; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002251242,0.00037393,0.0003170055,0.0002311194,0.0002952984,0.0007077249,0.0003333588,0.0004313763,0.001420146],"category_scores_gemma":[0.0002592262,0.0002247048,0.0001760446,0.00008318252,0.0002396032,0.0005685171,0.0004766338,0.001034361,0.0006458585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003124591,"about_ca_system_score_gemma":0.0002715859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002038623,"about_ca_topic_score_gemma":0.0005588735,"domain_scores_codex":[0.9997494,0.00003978973,0.00002233049,0.00005806756,0.00006536537,0.00006513836],"domain_scores_gemma":[0.9996825,0.00003320842,0.00009577977,0.00003230276,0.00004699576,0.0001092521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007285937,0.00002442236,0.0004141672,0.0000518218,0.000005093702,0.0000312984,0.00001875444,0.00009384145,0.9969748,0.0002818985,0.00004889695,0.001982129],"study_design_scores_gemma":[0.00004471101,0.0008330011,0.02088718,0.00004079472,0.0000319858,0.0004703607,0.00010439,0.001783856,0.967911,0.0005763348,0.007305533,0.00001087254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843938,0.00519251,0.006752762,0.0001227693,0.00004366488,0.0000430678,0.00007793316,0.0002036799,0.003169913],"genre_scores_gemma":[0.9948747,0.0007796518,0.002473058,0.00005142351,0.00003026231,0.0000288336,0.00007888899,0.00002939517,0.001653852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001420146,"threshold_uncertainty_score":0.004750848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030215857663424,"score_gpt":0.231344480650436,"score_spread":0.2210423220738018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}