{"id":"W4297859093","doi":"10.1021/acs.bioconjchem.2c00364","title":"H<sub>4</sub>picoopa─Robust Chelate for <sup>225</sup>Ac/<sup>111</sup>In Theranostics","year":2022,"lang":"ca","type":"article","venue":"Bioconjugate Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; Terry Fox Research Institute; TRIUMF","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Biodistribution; Chelation; Radiochemistry; Ligand (biochemistry); Conjugated system; DOTA; Spect imaging; Radionuclide therapy; Nuclear magnetic resonance spectroscopy; Nuclear chemistry; Nuclear medicine; Stereochemistry; In vitro; Inorganic chemistry; Organic chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008148147,0.0002583422,0.0001537681,0.0001239417,0.0001541207,0.0002186103,0.0002149939,0.0001800788,0.001548316],"category_scores_gemma":[0.00008721452,0.0001138033,0.0001423322,0.0001040995,0.000150728,0.0001217416,0.0002310689,0.0001994731,0.0006750115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003083957,"about_ca_system_score_gemma":0.0001832851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007029424,"about_ca_topic_score_gemma":0.0008352216,"domain_scores_codex":[0.9999313,0.000009857678,0.00000381142,0.00001511085,0.00001998253,0.00001987246],"domain_scores_gemma":[0.9999665,0.000004247589,0.000008886894,0.000004187819,0.000007641514,0.000008448347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001503271,0.00002024871,0.0002303499,0.0002045455,0.00001498573,0.0000938075,0.00003277401,0.000393715,0.9873733,0.00102363,0.0007614879,0.009700919],"study_design_scores_gemma":[0.00000914267,0.0001474521,0.0007624747,0.000006868342,0.00001555206,0.0001695313,0.00001636046,0.001448235,0.9830442,0.00006303126,0.01430884,0.000008199978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947772,0.004564052,0.02830052,0.0002792021,0.0001184829,0.0001730185,0.0004969498,0.001121546,0.01717418],"genre_scores_gemma":[0.9820632,0.0007731651,0.009978399,0.0001236177,0.00001653854,0.00008315781,0.0002898216,0.00007518343,0.006596973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548316,"threshold_uncertainty_score":0.005179644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0287941076637082,"score_gpt":0.2770158014416722,"score_spread":0.248221693777964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}