{"id":"W4297876224","doi":"10.1093/femsre/fuac040","title":"New antiretroviral inhibitors and HIV-1 drug resistance: more focus on 90% HIV-1 isolates?","year":2022,"lang":"en","type":"review","venue":"FEMS Microbiology Reviews","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Western University","keywords":"Cart; Drug resistance; Biology; Human immunodeficiency virus (HIV); Drug; HIV drug resistance; Antiretroviral therapy; Virology; Viral load; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006760069,0.00124345,0.005270642,0.0004709495,0.0002674357,0.00003618812,0.0003573987,0.0005200541,0.00131327],"category_scores_gemma":[0.0001304272,0.0008541351,0.001082935,0.0006100551,0.0001815529,0.00005713747,0.0003140481,0.001262341,0.002213142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005257513,"about_ca_system_score_gemma":0.0006084805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006415173,"about_ca_topic_score_gemma":0.00001385765,"domain_scores_codex":[0.9954009,0.0006313472,0.001716488,0.001388614,0.0001064398,0.0007562087],"domain_scores_gemma":[0.9974908,0.0002417483,0.0009622797,0.0009504224,0.00002811324,0.0003266556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004211871,0.0000931157,0.00009546786,0.005975274,0.0003425028,0.0001107302,0.0002407178,4.237229e-9,0.00001221015,0.00003285734,0.5250322,0.4680228],"study_design_scores_gemma":[0.00105807,0.0001207906,0.000002281478,0.01673823,0.001818168,0.000458608,0.00002488996,5.137457e-8,0.000008545869,0.000009797698,0.9790693,0.0006912708],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003017713,0.9913265,0.000004893122,0.001866275,0.0006804871,0.003651888,0.0002518102,0.0001067005,0.002081324],"genre_scores_gemma":[7.524125e-7,0.781695,0.001110544,0.000287323,0.0003785572,0.0002973088,0.003118182,0.000113452,0.2129989],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4673315,"threshold_uncertainty_score":0.9995996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02928404632685996,"score_gpt":0.3007547100095411,"score_spread":0.2714706636826811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}