{"id":"W4297897316","doi":"10.2139/ssrn.4224905","title":"HIV-1 Germline-Targeting Vaccine Regimen Selects for Rare Immunoglobulin Insertions and Deletions Typical of VRC01-Class Antibodies","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Germline; Antibody; Virology; Human immunodeficiency virus (HIV); Regimen; Medicine; Biology; Genetics; Immunology; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316757,0.0002864228,0.0002846257,0.0002137885,0.0001882146,0.0003764485,0.0002293975,0.0003431174,0.003549609],"category_scores_gemma":[0.0002897338,0.0001155481,0.0001657256,0.0001448571,0.0001593159,0.0001616828,0.0001186316,0.0007069333,0.0006204383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001853994,"about_ca_system_score_gemma":0.0002214134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003734725,"about_ca_topic_score_gemma":0.0008259179,"domain_scores_codex":[0.9998524,0.00002106741,0.000008731364,0.00003319424,0.00002709114,0.00005756126],"domain_scores_gemma":[0.9998604,0.00005668531,0.00002089207,0.00001881052,0.00001358074,0.00002960569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004143054,0.0008110541,0.001953874,0.00003025884,0.00002234707,0.0002730077,0.00002396691,0.0004384804,0.9797323,0.0003121967,0.0005035248,0.0154847],"study_design_scores_gemma":[0.0003334227,0.01302483,0.02885683,0.00003232348,0.0001600237,0.009016634,0.0001446637,0.00738024,0.9312444,0.0003884746,0.009392654,0.00002554456],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955732,0.000294358,0.0008563828,0.0000717763,0.00002812736,0.00004346632,0.0001653933,0.00009343146,0.002873853],"genre_scores_gemma":[0.9973491,0.0001441985,0.0007840628,0.00008100877,0.00001129431,0.00001931949,0.0002969039,0.00002641585,0.001287574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003549609,"threshold_uncertainty_score":0.01187462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005275898445642695,"score_gpt":0.2229227788338973,"score_spread":0.2176468803882546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}