{"id":"W4297899746","doi":"10.3389/fmolb.2022.897929","title":"Systemic tryptophan homeostasis","year":2022,"lang":"en","type":"review","venue":"Frontiers in Molecular Biosciences","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Walloon excellence in life sciences and biotechnology; Fondation contre le Cancer; Fonds De La Recherche Scientifique - FNRS; Université Catholique de Louvain; European Commission; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Ludwig Institute for Cancer Research","keywords":"Tryptophan; Kynurenine; Catabolism; Kynurenic acid; Kynurenine pathway; Biochemistry; Xanthurenic acid; Biology; Chemistry; Metabolism; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002676594,0.0007747392,0.0008999033,0.0006443119,0.0006687393,0.001562277,0.0006220271,0.001060243,0.01270431],"category_scores_gemma":[0.0006926189,0.0002018227,0.0005928597,0.000380654,0.0005469676,0.0007419481,0.001270012,0.001425498,0.003419144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001136666,"about_ca_system_score_gemma":0.0009453898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001399862,"about_ca_topic_score_gemma":0.0008762084,"domain_scores_codex":[0.9997031,0.0000444509,0.00002683924,0.00008526483,0.00007218694,0.00006808688],"domain_scores_gemma":[0.9997415,0.00002902291,0.00006811086,0.00003954549,0.00005850222,0.0000632914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003998014,0.0006040215,0.02947067,0.006198372,0.001147135,0.02467903,0.0008112456,0.001195478,0.3345841,0.02844775,0.048537,0.5203272],"study_design_scores_gemma":[0.0004808871,0.002017137,0.05828196,0.001811717,0.00111919,0.09566494,0.0007318185,0.003811172,0.07895017,0.02494404,0.7319963,0.0001905932],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4148471,0.3048483,0.06886027,0.01100457,0.003835504,0.001238252,0.008850086,0.005984086,0.1805319],"genre_scores_gemma":[0.888849,0.04398844,0.01067741,0.005229695,0.0007820486,0.0005498417,0.003976865,0.0004292291,0.04551744],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01270431,"threshold_uncertainty_score":0.04250014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0383690097179738,"score_gpt":0.2947907266117117,"score_spread":0.2564217168937379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}