{"id":"W4297900463","doi":"10.3389/fcell.2022.938709","title":"Acquisition and maintenance of pluripotency are influenced by fibroblast growth factor, leukemia inhibitory factor, and 2i in bovine-induced pluripotent stem cells","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"SOX2; Induced pluripotent stem cell; Leukemia inhibitory factor; Embryonic stem cell; KOSR; KLF4; Biology; Cell biology; Rex1; Stem cell; Homeobox protein NANOG; Basic fibroblast growth factor; Immunology; Growth factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001709951,0.0002612491,0.0003581535,0.0002215922,0.0001155259,0.00001416493,0.000181106,0.000211061,0.00001457893],"category_scores_gemma":[0.00001207845,0.0002612126,0.00003338454,0.0001679447,0.0002241731,0.00001679799,0.000615971,0.0002697479,7.794062e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002167721,"about_ca_system_score_gemma":0.0001464211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001407745,"about_ca_topic_score_gemma":0.00003486208,"domain_scores_codex":[0.9981151,0.0001962756,0.0004311332,0.0006622756,0.0001561377,0.0004390274],"domain_scores_gemma":[0.9995301,0.00002191548,0.0001621439,0.0001260153,0.00003868888,0.0001211686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002581068,0.00005604394,0.1420184,0.0001198147,0.0000188347,0.00001224848,0.0002716852,0.000005179042,0.8544652,0.000002212184,0.001077474,0.001694833],"study_design_scores_gemma":[0.002973109,0.0008511855,0.0689287,0.00007224106,0.000005005218,0.00003439308,0.003379583,0.000112925,0.9207207,0.0001167397,0.002254399,0.0005510171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955389,0.00339397,0.000120633,0.00004876684,0.0001930127,0.0003682318,0.0002229918,0.000007077642,0.0001064251],"genre_scores_gemma":[0.9970669,0.001674633,0.0006994317,0.000111574,0.00001460719,0.00004902802,0.00009966159,0.00001963088,0.000264565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07308967,"threshold_uncertainty_score":0.999984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006886320779154183,"score_gpt":0.2066502241833376,"score_spread":0.1997639034041834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}