{"id":"W4297907916","doi":"10.2533/chimia.2000.669","title":"Structure-Activity Relationships of Substituted 2,3,4,4a,5,10b-Hexahydro-benz[h]isoquinoline-6(1H)-ones as 5-HT2C Receptor Antagonists","year":2000,"lang":"en","type":"article","venue":"CHIMIA International Journal for Chemistry","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Isoquinoline; Stereochemistry; Chemistry; Receptor; Diastereomer; Selectivity; 5-HT2C receptor; 5-HT receptor; Biochemistry; Serotonin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003349078,0.0003036362,0.0003562159,0.00005246939,0.0002804878,0.0001197771,0.0006729299,0.0004019064,0.01936097],"category_scores_gemma":[0.001159068,0.0002587158,0.0003511489,0.0001050882,0.0001587769,0.0002475486,0.00004716469,0.0005988464,0.00003592318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002487144,"about_ca_system_score_gemma":0.0001805506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001705301,"about_ca_topic_score_gemma":0.000003612437,"domain_scores_codex":[0.9978902,0.00004103206,0.0007122424,0.0003898574,0.0006650458,0.0003015863],"domain_scores_gemma":[0.9980086,0.0003258373,0.0005642412,0.0002607475,0.0006588165,0.0001817308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007774901,0.0002002423,0.002186645,0.00007405369,0.0002526218,0.000006153198,0.00008499878,0.0002553737,0.9806936,0.00008383852,0.0007268479,0.01465813],"study_design_scores_gemma":[0.001140389,0.00002635357,0.002302472,0.000168237,0.00006229113,0.0002601715,0.00008225453,0.0008670259,0.9826974,0.002186329,0.009887223,0.0003198025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933584,0.0001490991,0.00009327289,0.0008486166,0.0005087812,0.00009720955,0.0004330533,0.000057354,0.004454155],"genre_scores_gemma":[0.9950771,0.000278824,0.0008861555,0.00005396173,0.001499615,0.00001772058,0.0004597165,0.00003031787,0.001696547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01932504,"threshold_uncertainty_score":0.9999865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03601329973599248,"score_gpt":0.308184302693878,"score_spread":0.2721710029578855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}