{"id":"W4297907916","doi":"10.2533/chimia.2000.669","title":"Structure-Activity Relationships of Substituted 2,3,4,4a,5,10b-Hexahydro-benz[h]isoquinoline-6(1H)-ones as 5-HT2C Receptor Antagonists","year":2000,"lang":"en","type":"article","venue":"CHIMIA International Journal for Chemistry","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Isoquinoline; Stereochemistry; Chemistry; Receptor; Diastereomer; Selectivity; 5-HT2C receptor; 5-HT receptor; Biochemistry; Serotonin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154155,0.0003279849,0.0004422965,0.0001714801,0.0001027047,0.000157809,0.0003157339,0.0002206289,0.002543846],"category_scores_gemma":[0.0001771192,0.0001633745,0.0001768486,0.0001431364,0.0001636984,0.0001281214,0.0001164661,0.0003734843,0.0005506339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001254475,"about_ca_system_score_gemma":0.0001723772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005991351,"about_ca_topic_score_gemma":0.002555911,"domain_scores_codex":[0.9999071,0.0000362869,0.000006561381,0.00001261425,0.00001513177,0.00002220209],"domain_scores_gemma":[0.9999287,0.00001446806,0.00001680992,0.000006189563,0.00001322198,0.00002064323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001731175,0.0003139211,0.0004640834,0.0002650544,0.00004511357,0.0002112606,0.00007817365,0.0008789324,0.9824231,0.0003332379,0.0002410955,0.01301494],"study_design_scores_gemma":[0.001008412,0.03412213,0.0163913,0.00008827856,0.000288268,0.001606729,0.000134151,0.00244515,0.92587,0.0002446879,0.01773639,0.00006452674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838545,0.01006045,0.0008995382,0.0001170828,0.00007001078,0.0001036666,0.0004829489,0.00004857462,0.004363396],"genre_scores_gemma":[0.9869207,0.007153321,0.001434944,0.0001335214,0.00003249569,0.00005352985,0.0006645159,0.00001268223,0.003594369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002543846,"threshold_uncertainty_score":0.008509994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03601329973599248,"score_gpt":0.308184302693878,"score_spread":0.2721710029578855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}