{"id":"W4297963355","doi":"10.1055/a-1953-1509","title":"Biocatalytic Synthesis of α,β-Unsaturated 2-Keto Acids and Derivatives Using the Promiscuous Aldolase, NahE","year":2022,"lang":"en","type":"article","venue":"Synthesis","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; University of Saskatchewan","keywords":"Chemistry; Yield (engineering); Benzaldehyde; Aldolase A; Aldol condensation; Substrate (aquarium); Organic chemistry; Catalysis; Aldol reaction; Condensation reaction; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003267755,0.000174018,0.0002340497,0.00005369206,0.000289285,0.00001835645,0.0002712537,0.00006687435,0.00006716894],"category_scores_gemma":[0.0003967504,0.0001270765,0.00009612885,0.0001824015,0.0002167718,0.000005378564,0.0003118164,0.00009603427,9.813319e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001394301,"about_ca_system_score_gemma":0.00008159317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006305506,"about_ca_topic_score_gemma":0.000005000581,"domain_scores_codex":[0.9988683,0.0002012681,0.000217941,0.0003142209,0.0001695739,0.0002286873],"domain_scores_gemma":[0.9992403,0.0001074388,0.000141533,0.0004098949,0.00004758094,0.00005330198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001012341,0.00005766339,0.0008036231,0.00003546313,0.000169135,0.000002212319,0.0001917821,0.0001013742,0.9883074,0.00008051833,0.0003402086,0.009809427],"study_design_scores_gemma":[0.0001256975,0.00005696391,0.002651057,0.0000150406,0.0001389912,0.00003879264,0.001300856,0.0001862401,0.9823657,0.00003557199,0.01288866,0.0001963921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964515,0.002392746,0.0001672378,0.0002334772,0.00009240751,0.0002134954,0.00009379072,0.00001152996,0.0003437928],"genre_scores_gemma":[0.9985014,0.0001916905,0.0007468076,0.00009939006,0.00007447977,0.0001003659,0.0000105861,0.00003014518,0.0002451558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01254845,"threshold_uncertainty_score":0.518203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224600124222146,"score_gpt":0.2344372227218158,"score_spread":0.2221912214795944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}