{"id":"W4297981942","doi":"10.1016/j.annonc.2022.08.080","title":"LBA74 Genomic biomarkers in peripheral blood (PB) from patients (pts) enrolled in the JAVELIN Bladder 100 trial of avelumab first-line (1L) maintenance in advanced urothelial carcinoma (aUC)","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Javelin; Avelumab; Urothelial carcinoma; Peripheral blood; Merkel cell carcinoma; Internal medicine; Oncology; Bladder cancer; Urology; Carcinoma; Immunotherapy; Cancer; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000265539,0.0002801282,0.0004856556,0.0003250216,0.0003543957,0.000767754,0.0002654309,0.0004589138,0.003233325],"category_scores_gemma":[0.000717461,0.0002166579,0.0002421278,0.0004279304,0.0001989886,0.0003449084,0.0002513864,0.0005701293,0.0005532498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003331339,"about_ca_system_score_gemma":0.0003068566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008824529,"about_ca_topic_score_gemma":0.001394243,"domain_scores_codex":[0.9997731,0.00007092035,0.00001144484,0.00006364702,0.00003361138,0.00004735677],"domain_scores_gemma":[0.9998274,0.00003709588,0.00004794799,0.00001780632,0.00002067519,0.00004917022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09516162,0.002453638,0.6950403,0.0003240566,0.001342942,0.0006552987,0.0003568129,0.001417917,0.04940888,0.0005406882,0.0115868,0.1417111],"study_design_scores_gemma":[0.007296145,0.02677925,0.9359632,0.00008610021,0.001043435,0.00154713,0.0003999203,0.002432185,0.0111331,0.0009082966,0.01236181,0.00004943669],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955056,0.001177627,0.0001978098,0.000200323,0.00004769668,0.00005465902,0.001473929,0.00003330454,0.001309066],"genre_scores_gemma":[0.9957609,0.0002399144,0.0001828685,0.0002473448,0.00004830868,0.00006333148,0.00192291,0.000007017911,0.001527518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003233325,"threshold_uncertainty_score":0.01081651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03911698986008975,"score_gpt":0.3208681089885789,"score_spread":0.2817511191284891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}