{"id":"W4297986259","doi":"10.1016/j.annonc.2022.08.029","title":"LBA5 Primary results of the phase III KEYNOTE-412 study: Pembrolizumab (pembro) with chemoradiation therapy (CRT) vs placebo plus CRT for locally advanced (LA) head and neck squamous cell carcinoma (HNSCC)","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pembrolizumab; Head and neck squamous-cell carcinoma; Placebo; Oncology; Head and neck; Head and neck cancer; Phases of clinical research; Basal cell; Internal medicine; Radiation therapy; Clinical trial; Surgery; Cancer; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002088066,0.001865224,0.002546477,0.0004645557,0.0005461648,0.001650678,0.001309094,0.001602707,0.01062296],"category_scores_gemma":[0.001418985,0.000594856,0.003121391,0.000449288,0.0007203934,0.0009507721,0.0004414073,0.003620794,0.002101299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001449715,"about_ca_system_score_gemma":0.001426432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002409261,"about_ca_topic_score_gemma":0.005812319,"domain_scores_codex":[0.9994986,0.0002430168,0.00002624411,0.00008398075,0.00003993175,0.0001082915],"domain_scores_gemma":[0.9994462,0.0001164905,0.0001292537,0.00003550351,0.0000382344,0.0002343178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.937514,0.006558623,0.001477409,0.001803884,0.003655081,0.00006943523,0.00006609356,0.0009784517,0.00594047,0.0003509501,0.005819088,0.03576645],"study_design_scores_gemma":[0.891784,0.08967572,0.008141822,0.0001783524,0.003255577,0.00009434308,0.00006764609,0.0007142242,0.001315903,0.000325233,0.004410792,0.00003635571],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9362332,0.02378672,0.001420525,0.00265465,0.001557901,0.004854203,0.01458302,0.0005247593,0.01438505],"genre_scores_gemma":[0.9644559,0.005651637,0.001970858,0.00327182,0.0006567029,0.003634343,0.01044069,0.00008283302,0.009835126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01062296,"threshold_uncertainty_score":0.0355373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03766164934901792,"score_gpt":0.3400283840036157,"score_spread":0.3023667346545977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}