{"id":"W4297991581","doi":"10.1101/2022.09.28.22280443","title":"POPULATION PHARMACOKINETICS OF BENZNIDAZOLE IN NEONATES, INFANTS AND CHILDREN USING A NEW PEDIATRIC FORMULATION","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Agencia Española de Cooperación Internacional para el Desarrollo; Direktion für Entwicklung und Zusammenarbeit; United States Agency for International Development; Consejo Nacional de Investigaciones Científicas y Técnicas; Drugs for Neglected Diseases initiative; Ministerie van Buitenlandse Zaken; Governo Brasil","keywords":"Benznidazole; Cmin; Medicine; Interquartile range; Pharmacokinetics; Cmax; Pediatrics; Population; Internal medicine; Trypanosoma cruzi","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001021578,0.0003214672,0.0005287336,0.0001983084,0.00008763218,0.000403059,0.0002734061,0.0002154692,0.0008951959],"category_scores_gemma":[0.0009177751,0.0001639002,0.0001949146,0.0002350262,0.0002412321,0.0002613156,0.0001867234,0.0005404979,0.0001629092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000437695,"about_ca_system_score_gemma":0.0003819242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008960211,"about_ca_topic_score_gemma":0.00083865,"domain_scores_codex":[0.9994621,0.000311672,0.00002975639,0.00007799696,0.0000898489,0.00002865905],"domain_scores_gemma":[0.9995479,0.00009092232,0.0001916758,0.0000356786,0.00007654382,0.00005723707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.04907673,0.003020658,0.2291273,0.00106698,0.0007311787,0.0006733962,0.0008941766,0.007242304,0.3763795,0.00112323,0.002642701,0.3280219],"study_design_scores_gemma":[0.009602342,0.2012293,0.5509145,0.0002550553,0.001161887,0.005580096,0.0009274108,0.02116494,0.1582526,0.0006823211,0.05009362,0.0001361303],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899921,0.004615194,0.003701641,0.0001065759,0.00002120122,0.0001910421,0.0004387291,0.00004197618,0.0008914793],"genre_scores_gemma":[0.9897573,0.002709398,0.005960583,0.000083578,0.00002845552,0.0002333547,0.0005342418,0.00001667045,0.0006764698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021578,"threshold_uncertainty_score":0.005402684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03914541594297658,"score_gpt":0.3508447377051478,"score_spread":0.3116993217621712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}