{"id":"W4297993336","doi":"10.17615/hs58-7865","title":"A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk","year":2017,"lang":"en","type":"article","venue":"University of Southern Denmark Research Portal (University of Southern Denmark)","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biomedical Research Council; Korea Centers for Disease Control and Prevention; Medical Research Council; Centers for Disease Control and Prevention; Diabetesliitto; Sydäntutkimussäätiö; Eesti Teadusagentuur; Samfundet Folkhälsan; Tartu Ülikool; Emil Aaltosen Säätiö; Helsingin ja Uudenmaan Sairaanhoitopiiri; Atlantic Canada Opportunities Agency; Juho Vainion Säätiö; Suomen Kulttuurirahasto; Augustinus Fonden; Helsefonden; Bundesministerium für Bildung und Forschung; Kela; European Commission; Folkhälsanin Tutkimussäätiö; British Heart Foundation; Sundhed og Sygdom, Det Frie Forskningsråd; Foundation for Cardiovascular Research; Finska Läkaresällskapet; Sihtasutus Archimedes; Jalmari ja Rauha Ahokkaan Säätiö; Diabetestutkimussäätiö; Wellcome Trust; Hjerteforeningen; Danmarks Frie Forskningsfond; Helmholtz Zentrum München; American Diabetes Association","keywords":"Type 2 diabetes; Insulin; Medicine; Diabetes mellitus; Population; Internal medicine; Endocrinology; Environmental health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002200484,0.0002062867,0.0005272164,0.0004125469,0.001147234,0.00004775046,0.0005070422,0.0002469398,0.0009771609],"category_scores_gemma":[0.000964931,0.0001903463,0.0002076642,0.0005715748,0.0007575045,0.0002271158,0.0002660581,0.0007843235,0.00005408762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001099191,"about_ca_system_score_gemma":0.0002038116,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01282142,"about_ca_topic_score_gemma":0.004060748,"domain_scores_codex":[0.9974434,0.0005035945,0.0001959075,0.0004394068,0.0009968203,0.0004208935],"domain_scores_gemma":[0.9977121,0.000353535,0.0005442593,0.0006528217,0.0005783191,0.000158946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005331065,0.0001937756,0.9732017,0.00009935842,0.0005673171,0.0004258353,0.01987337,0.000007863494,0.0009197161,0.00002453409,0.00008731495,0.004066116],"study_design_scores_gemma":[0.003057471,0.0002343634,0.8445334,0.0004292579,0.0002455265,0.00001591031,0.1506139,0.0004450685,0.00002565262,0.0001435107,0.00005220798,0.0002037279],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953992,0.00008264338,0.00007786343,0.0002355168,0.00002592072,0.00046193,0.0003010842,0.00001900312,0.003396785],"genre_scores_gemma":[0.9982346,0.00008415417,0.0002723958,0.00001257817,0.0000256149,1.102615e-7,0.00003806625,0.0000226294,0.001309867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1307405,"threshold_uncertainty_score":0.9999361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03171975015153024,"score_gpt":0.2493141900717247,"score_spread":0.2175944399201944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}