{"id":"W4297996509","doi":"10.3389/fimmu.2022.1020159","title":"Immunological study of COVID-19 vaccine candidate based on recombinant spike trimer protein from different SARS-CoV-2 variants of concern","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Universidad Nacional de La Plata; Consejo Nacional de Investigaciones Científicas y Técnicas","keywords":"Immunogenicity; Virology; Neutralizing antibody; Antibody; Recombinant DNA; Biology; Booster dose; Immune system; Immunology; Titer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001975448,0.0002992401,0.0001748612,0.0001285249,0.0000768535,0.000124558,0.0001370003,0.0002347395,0.0005591082],"category_scores_gemma":[0.0001191979,0.00007886961,0.0002498616,0.00008687312,0.0001042335,0.0002004755,0.00008700112,0.0004025913,0.0001127147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000179925,"about_ca_system_score_gemma":0.0001001969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003490499,"about_ca_topic_score_gemma":0.0003789848,"domain_scores_codex":[0.9998997,0.00001939796,0.000007083898,0.00001791328,0.00003162978,0.00002434938],"domain_scores_gemma":[0.999954,0.000009572994,0.00001032403,0.000003327399,0.00001407445,0.000008646516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001295483,0.0001033496,0.0003553439,0.00003925783,0.000007437754,0.0000324781,0.00001612259,0.000149885,0.9980292,0.0000285377,0.00002369837,0.001085161],"study_design_scores_gemma":[0.00004826588,0.01004821,0.008924806,0.00001170811,0.00006001735,0.0004887419,0.00007381797,0.001977889,0.9765388,0.00004805901,0.001772832,0.00000677359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987499,0.0003954106,0.0004144199,0.00001673504,0.00001263207,0.00001905311,0.0000420855,0.000004879664,0.0003449053],"genre_scores_gemma":[0.9978222,0.0003844363,0.0008753915,0.0000443842,0.00001210373,0.00001890862,0.0002333216,0.000003549478,0.0006056554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005591082,"threshold_uncertainty_score":0.001870453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04713612581831157,"score_gpt":0.33508384879061,"score_spread":0.2879477229722985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}