{"id":"W4297997099","doi":"10.1182/blood.2022017560","title":"Lost in translation: cytoplasmic UBA1 and VEXAS syndrome","year":2022,"lang":"en","type":"letter","venue":"Blood","topic":"Otitis Media and Relapsing Polychondritis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Translation (biology); Medicine; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007262264,0.0002318324,0.0005093085,0.0003085865,0.00005028765,0.00002036465,0.00008403145,0.0005404995,0.001440441],"category_scores_gemma":[0.00001919093,0.0002312794,0.00009488196,0.0001983967,0.00008962737,0.00003628243,0.00002807443,0.00199639,0.00008733051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003707297,"about_ca_system_score_gemma":0.0001166807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003594585,"about_ca_topic_score_gemma":0.00002308473,"domain_scores_codex":[0.9985682,0.00006510919,0.0002895739,0.0003946701,0.0003666587,0.0003157383],"domain_scores_gemma":[0.9994733,0.0001071095,0.00006595896,0.0002677713,0.00001169529,0.00007413087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003334559,0.0002629087,0.007322744,0.0008940633,0.0001795142,0.05547527,0.0004692875,2.642464e-7,0.0001211507,0.000004549895,0.9342474,0.0009894622],"study_design_scores_gemma":[0.004243033,0.0004468749,0.002372003,0.0005104162,0.0004179177,0.01492609,0.0000185919,0.000002364385,0.00005381223,0.00004291806,0.9767066,0.0002593595],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1920495,0.01672719,0.000002685932,0.7660353,0.01075906,0.0009987246,0.0002007009,0.0001201515,0.01310669],"genre_scores_gemma":[0.03867542,0.005534817,0.001724558,0.7378283,0.006516087,0.0002014764,0.003129164,0.0004660171,0.2059242],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1928175,"threshold_uncertainty_score":0.9994724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01460980513551392,"score_gpt":0.2315632194828842,"score_spread":0.2169534143473703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}