{"id":"W4298006454","doi":"10.1038/s41467-022-33367-w","title":"MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Cambridge Biomedical Research Centre; Fondation Botnar; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; École Polytechnique Fédérale de Lausanne; Wellcome; National Science Foundation; Canadian Institutes of Health Research; Eidgenössische Technische Hochschule Zürich; Functional Genomics Center Zurich; National Institute for Health and Care Research; Government of Canada; Wellcome Trust; Fondation Bertarelli","keywords":"microRNA; Melanocortin; Biology; Energy homeostasis; Melanocortin 4 receptor; Gene; Melanocortin 3 receptor; Glucose homeostasis; Regulation of gene expression; Leptin; Genetics; Cell biology; Receptor; Internal medicine; Endocrinology; Melanocortin receptor; Obesity; Medicine; Insulin resistance","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043424,0.000270132,0.0001913497,0.0002486676,0.0001861482,0.0003484509,0.0002240164,0.0002152987,0.0004912241],"category_scores_gemma":[0.0001448107,0.000119386,0.0002068151,0.00009972374,0.0002355438,0.0001670118,0.0002730474,0.0002790438,0.000315764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002696123,"about_ca_system_score_gemma":0.0002289714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002660521,"about_ca_topic_score_gemma":0.0006338457,"domain_scores_codex":[0.999893,0.0000192676,0.000006951554,0.00002502129,0.00003727262,0.0000184846],"domain_scores_gemma":[0.9999436,0.000006907483,0.00001695127,0.000003690278,0.00001553188,0.00001338475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001411909,0.00001907694,0.001508462,0.00006026775,0.00002602085,0.0002541164,0.00002960371,0.0002077352,0.983704,0.001128778,0.0002962982,0.01262438],"study_design_scores_gemma":[0.0000486065,0.0003466845,0.04594206,0.000063725,0.0001053704,0.001499637,0.0001730224,0.00453594,0.9235787,0.002600694,0.02107974,0.00002580148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9512392,0.01994431,0.01331861,0.0005959538,0.0003130403,0.00004509893,0.0003828561,0.0004461685,0.01371467],"genre_scores_gemma":[0.9852013,0.005524417,0.006020895,0.0001775052,0.00005291406,0.00002661102,0.0003600406,0.00005520188,0.002581052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004912241,"threshold_uncertainty_score":0.001956165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03099557040167483,"score_gpt":0.2780089370685887,"score_spread":0.2470133666669139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}