{"id":"W4298007555","doi":"10.1016/j.xcrm.2022.100774","title":"A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo","year":2022,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Astellas Hong Kong; Rogel Cancer Center, University of Michigan; General Research Fund of Shanghai Normal University; National Institutes of Health; Science and Technology Program of Hunan Province; T. Von Zastrow Foundation; Hong Kong Government; Canadian Institutes of Health Research; Österreichischen Akademie der Wissenschaften; Innovative Medicines Initiative; Innovative Medicines Canada; Health and Medical Research Fund; Pfizer Hong Kong; Universität für Bodenkultur Wien; Sanming Project of Medicine in Shenzhen; Defense Threat Reduction Agency; National Key Research and Development Program of China; Vienna Science and Technology Fund; Food and Health Bureau; University of Hong Kong; Guangzhou Regenerative Medicine and Health Guangdong Laboratory; Research Grants Council, University Grants Committee; Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung; Austrian Science Fund; University of Michigan","keywords":"Virology; In vivo; Middle East respiratory syndrome coronavirus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus; Broad spectrum; Coronavirus disease 2019 (COVID-19); Biology; 2019-20 coronavirus outbreak; Chemistry; Medicine; Outbreak; Infectious disease (medical specialty); Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001527664,0.0004378477,0.0008617212,0.001053744,0.0002237259,0.00003205265,0.0001257953,0.0001755148,0.00009410119],"category_scores_gemma":[0.0004859995,0.0004091727,0.0001351815,0.001461856,0.0002369335,0.0001517433,0.0002593612,0.001205668,0.00001094761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005176711,"about_ca_system_score_gemma":0.0004537343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006492352,"about_ca_topic_score_gemma":0.0003243016,"domain_scores_codex":[0.9957899,0.0001629414,0.0009767317,0.0009921545,0.001299937,0.0007783045],"domain_scores_gemma":[0.9985971,0.0001257755,0.0002994188,0.0007527326,0.0001254504,0.00009948443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002380826,0.000340684,0.06910394,0.0002284092,0.00005598816,0.008618111,0.0008826322,0.000006176138,0.9170799,0.00001922063,0.002039334,0.001387464],"study_design_scores_gemma":[0.00323926,0.001195544,0.006684556,0.0001617185,0.0001144799,0.004474507,0.0002028252,0.000369031,0.8287262,0.0001926228,0.1542943,0.0003449774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820958,0.003530806,0.0003572195,0.0008843254,0.0008649737,0.001069522,0.000003293438,0.000184523,0.01100958],"genre_scores_gemma":[0.9845322,0.00009244145,0.0000479928,0.01444436,0.0002983995,0.000169509,0.00001523362,0.00009503809,0.0003047592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1522549,"threshold_uncertainty_score":0.999836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03204634553831429,"score_gpt":0.3197187495097463,"score_spread":0.287672403971432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}