{"id":"W4298007555","doi":"10.1016/j.xcrm.2022.100774","title":"A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo","year":2022,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Astellas Hong Kong; Rogel Cancer Center, University of Michigan; General Research Fund of Shanghai Normal University; National Institutes of Health; Science and Technology Program of Hunan Province; T. Von Zastrow Foundation; Hong Kong Government; Canadian Institutes of Health Research; Österreichischen Akademie der Wissenschaften; Innovative Medicines Initiative; Innovative Medicines Canada; Health and Medical Research Fund; Pfizer Hong Kong; Universität für Bodenkultur Wien; Sanming Project of Medicine in Shenzhen; Defense Threat Reduction Agency; National Key Research and Development Program of China; Vienna Science and Technology Fund; Food and Health Bureau; University of Hong Kong; Guangzhou Regenerative Medicine and Health Guangdong Laboratory; Research Grants Council, University Grants Committee; Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung; Austrian Science Fund; University of Michigan","keywords":"Virology; In vivo; Middle East respiratory syndrome coronavirus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus; Broad spectrum; Coronavirus disease 2019 (COVID-19); Biology; 2019-20 coronavirus outbreak; Chemistry; Medicine; Outbreak; Infectious disease (medical specialty); Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009996234,0.000300291,0.0001648184,0.00008690659,0.00009323454,0.0001573627,0.0001768702,0.0002397698,0.0004310281],"category_scores_gemma":[0.00004863062,0.00008203072,0.0001583852,0.00006608705,0.0001743286,0.0001356027,0.0001262178,0.0003606646,0.0001280339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003221486,"about_ca_system_score_gemma":0.0002115613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003331079,"about_ca_topic_score_gemma":0.0007647973,"domain_scores_codex":[0.9999427,0.000009286466,0.000003245692,0.00001134205,0.00001813969,0.00001534626],"domain_scores_gemma":[0.999977,0.00000224285,0.000007556803,0.000002324676,0.000004171961,0.000006743683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004506037,0.00006194932,0.0001086482,0.00001924076,0.000005414186,0.0000190956,0.000002773433,0.0002261409,0.9980354,0.0001223791,0.0000519669,0.001301956],"study_design_scores_gemma":[0.00003073329,0.0007225231,0.001084644,0.000002668101,0.0000143842,0.0001984322,0.00000848925,0.001727107,0.9933999,0.00006031546,0.00274514,0.000005707561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898526,0.0006367184,0.007090525,0.0001564958,0.00003561145,0.00006620605,0.0001889614,0.0001284219,0.001844366],"genre_scores_gemma":[0.9887229,0.0004082157,0.008426273,0.0001599976,0.000007900368,0.0000373982,0.000298971,0.00001001223,0.001928395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004310281,"threshold_uncertainty_score":0.002337337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03204634553831429,"score_gpt":0.3197187495097463,"score_spread":0.287672403971432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}