{"id":"W4298055503","doi":"10.1016/j.ymgme.2022.09.008","title":"Cardiac-specific deficiency of 3-hydroxy-3-methylglutaryl coenzyme A lyase in mice causes cardiomyopathy and a distinct pattern of acyl-coenzyme A-related biomarkers","year":2022,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital; Centre Hospitalier Universitaire Sainte-Justine; Université de Sherbrooke; Université de Montréal","funders":"Lady Davis Institute for Medical Research; Acorda Therapeutics","keywords":"Internal medicine; Endocrinology; Coenzyme A; Leucine; Cardiomyopathy; Metabolite; Biology; Metabolism; Chemistry; Reductase; Medicine; Heart failure; Biochemistry; Enzyme; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003192106,0.001316643,0.000540243,0.00217483,0.000357178,0.0006979313,0.0006356339,0.001069073,0.002065326],"category_scores_gemma":[0.0003440519,0.0009182172,0.0006110715,0.0005803204,0.001123013,0.0005263729,0.0005529918,0.001762715,0.0007313281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005079606,"about_ca_system_score_gemma":0.0003524887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005427488,"about_ca_topic_score_gemma":0.001137886,"domain_scores_codex":[0.9994705,0.00006370487,0.00007579461,0.0001719907,0.0001165485,0.0001015054],"domain_scores_gemma":[0.9987622,0.0001858758,0.0004955047,0.00009008996,0.00005263468,0.0004136683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003747186,0.00004634091,0.0003404881,0.00001770555,0.00001469426,0.0001983226,0.00001540248,0.00005400592,0.9982612,0.0002328706,0.00004560227,0.000398717],"study_design_scores_gemma":[0.000209507,0.0005133292,0.01768823,0.00002497853,0.0001255385,0.002155045,0.00009557469,0.001702595,0.9756576,0.0004926602,0.001310218,0.00002468962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985908,0.001163247,0.00878984,0.0003999682,0.0001074994,0.00005695591,0.00146713,0.0004588911,0.001648313],"genre_scores_gemma":[0.9868543,0.0009494761,0.004932979,0.0002383799,0.00005597132,0.0001176256,0.001541906,0.0003199595,0.004989374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00217483,"threshold_uncertainty_score":0.006909192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005155655378012478,"score_gpt":0.2092579936385184,"score_spread":0.2041023382605059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}