{"id":"W4298056505","doi":"","title":"Potent, Selective, and Cell-active Chemical Probe of Protein Lysine Methyltransferases G9a and GLP: Cell-Based Assays","year":2010,"lang":"en","type":"preprint","venue":"HAL (Le Centre pour la Communication Scientifique Directe)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Structural Genomics Consortium","funders":"","keywords":"Methyltransferase; Lysine; Cell; Chemistry; Biochemistry; Cell biology; Biology; Amino acid; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001100208,0.0003010618,0.0003258725,0.0001056673,0.0001301087,0.00008786,0.00032461,0.0005818941,0.00001437334],"category_scores_gemma":[0.0004329408,0.0003268803,0.0001249186,0.0001639048,0.000381192,0.000008437358,0.0004121499,0.0005108895,6.780879e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003947883,"about_ca_system_score_gemma":0.0004046077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005455993,"about_ca_topic_score_gemma":0.0004551391,"domain_scores_codex":[0.9972304,0.001194847,0.0003574334,0.0007747251,0.0002224622,0.0002201446],"domain_scores_gemma":[0.9970884,0.0001442925,0.0005426959,0.0009108532,0.001187107,0.0001267024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007593194,0.0002669428,0.0003434433,0.0002514592,0.00005368431,3.924583e-7,0.0003947448,0.00007138414,0.9912779,0.0001320854,0.00004454024,0.007087518],"study_design_scores_gemma":[0.0007641484,0.000002959496,0.001240824,0.0002911286,0.00007768243,0.000003684123,0.00001889542,0.002596532,0.9934539,0.0003405371,0.0009148854,0.0002947894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9351431,0.001985898,0.05840257,0.001126472,0.00004997596,0.0008548107,0.0001252132,0.00003379629,0.002278222],"genre_scores_gemma":[0.9752376,0.0003246414,0.02270456,0.00001721384,0.00002799258,0.0001015447,0.0008844095,0.00004262418,0.0006594165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04009456,"threshold_uncertainty_score":0.9999183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005686699599714913,"score_gpt":0.2092064083150342,"score_spread":0.2035197087153193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}