{"id":"W4298087354","doi":"10.1016/j.gim.2022.08.025","title":"The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay","year":2022,"lang":"en","type":"article","venue":"Genetics in Medicine","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Dental and Craniofacial Research; NIHR Oxford Biomedical Research Centre; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; National Institute for Health and Care Research; Department of Health and Social Care; National Institutes of Health; Cancer Research UK; Wellcome Trust; McGill University","keywords":"Zebrafish; Hypogonadotropic hypogonadism; In vitro; Medicine; Kallmann syndrome; Endocrinology; Internal medicine; Biology; Cancer research; Hormone; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001441139,0.0003524819,0.0007457702,0.0003441811,0.0001959799,0.00002001395,0.0002647426,0.00008843176,0.00001533628],"category_scores_gemma":[0.001082159,0.0002592289,0.00002237761,0.0005700945,0.0004190083,0.00008797761,0.000346607,0.001028278,0.000001467952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000350479,"about_ca_system_score_gemma":0.0002590082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00035272,"about_ca_topic_score_gemma":0.001009774,"domain_scores_codex":[0.9965613,0.0005117143,0.0006123147,0.0009333837,0.0008373227,0.0005439669],"domain_scores_gemma":[0.9982443,0.0006060826,0.0002652688,0.0005952884,0.0001124791,0.0001766184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002499187,0.000244899,0.8963707,0.00006161386,0.00004624096,0.0001581413,0.001491421,0.0000492365,0.04988517,0.00000369447,0.00003649826,0.04915318],"study_design_scores_gemma":[0.006325133,0.0004634779,0.9885429,0.0003849664,0.00005362791,0.00003904259,0.0003767319,0.0004463361,0.002125241,0.0002349177,0.0007642202,0.0002434427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771348,0.01477408,0.0000428733,0.006742059,0.0001575938,0.001085369,0.00001324067,0.0000227145,0.00002732034],"genre_scores_gemma":[0.9980444,0.0007982263,0.000347374,0.0003941137,0.0001233233,0.0001945393,0.00002371809,0.00004444723,0.00002987979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09217214,"threshold_uncertainty_score":0.999986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540350287118363,"score_gpt":0.2499052479332734,"score_spread":0.2245017450620898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}