{"id":"W4298087354","doi":"10.1016/j.gim.2022.08.025","title":"The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay","year":2022,"lang":"en","type":"article","venue":"Genetics in Medicine","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Dental and Craniofacial Research; NIHR Oxford Biomedical Research Centre; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; National Institute for Health and Care Research; Department of Health and Social Care; National Institutes of Health; Cancer Research UK; Wellcome Trust; McGill University","keywords":"Zebrafish; Hypogonadotropic hypogonadism; In vitro; Medicine; Kallmann syndrome; Endocrinology; Internal medicine; Biology; Cancer research; Hormone; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958868,0.0003918832,0.0002242348,0.001413936,0.0003290441,0.000255749,0.0002515767,0.0004955241,0.001807358],"category_scores_gemma":[0.0003908151,0.0002134941,0.0003270953,0.0004599559,0.0005899022,0.0001997577,0.0003839867,0.0004258284,0.0001770231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001643446,"about_ca_system_score_gemma":0.0001293521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001524868,"about_ca_topic_score_gemma":0.001469612,"domain_scores_codex":[0.9998183,0.00002460476,0.00001968325,0.00004842372,0.00005781098,0.00003125472],"domain_scores_gemma":[0.99977,0.00007855422,0.00006812865,0.00002226531,0.00002052462,0.00004050448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00105598,0.00007694312,0.06316552,0.0001320813,0.000117905,0.01500421,0.0005980772,0.0001562842,0.9094763,0.0006998602,0.0004043261,0.00911236],"study_design_scores_gemma":[0.0001135497,0.0009164074,0.5683837,0.00004870348,0.000371999,0.0917289,0.0009391043,0.001661229,0.3286065,0.0007980762,0.006399441,0.000032364],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970378,0.0008141605,0.0008266449,0.0000827309,0.00001217478,0.000009775149,0.0002572957,0.00002254581,0.0009369513],"genre_scores_gemma":[0.9982178,0.0003081875,0.0006862255,0.00003947581,0.000006529844,0.000008942637,0.0001983822,0.00001050916,0.0005239155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001807358,"threshold_uncertainty_score":0.006046236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540350287118363,"score_gpt":0.2499052479332734,"score_spread":0.2245017450620898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}