{"id":"W4298087646","doi":"10.1177/13524585221125382","title":"Recurrent disability progression endpoints in multiple sclerosis clinical trials","year":2022,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Multiple sclerosis; Clinical trial; Proportional hazards model; Randomized controlled trial; Expanded Disability Status Scale; Marginal structural model; Clinical endpoint; Physical therapy; Physical medicine and rehabilitation; Internal medicine; Confidence interval; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.03383359,0.0007045961,0.002658005,0.0005828419,0.001841816,0.0002405152,0.0008685372,0.000271133,0.002205378],"category_scores_gemma":[0.04088983,0.0005725958,0.001663449,0.001291162,0.0008609278,0.000439251,0.001509849,0.004493107,0.0000796474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001901925,"about_ca_system_score_gemma":0.0004719453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001399935,"about_ca_topic_score_gemma":0.0002855363,"domain_scores_codex":[0.9801613,0.008877181,0.004709327,0.001385333,0.00317905,0.0016878],"domain_scores_gemma":[0.9887977,0.006645047,0.001491903,0.001211667,0.000489966,0.001363677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004321671,0.004302426,0.6159428,0.00007450323,0.000222462,0.00004345767,0.0005097554,0.0001082921,0.01621939,0.00000236228,0.005837767,0.3524151],"study_design_scores_gemma":[0.02268497,0.001837932,0.9543538,0.0009745011,0.0001370816,0.0001027952,0.001512322,0.006840102,0.001844086,0.00003337303,0.009117538,0.000561476],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869333,0.002078072,0.0002073741,0.004473808,0.002436793,0.003252792,0.0002772136,0.0001687212,0.0001719243],"genre_scores_gemma":[0.98866,0.004441512,0.004026319,0.0003662224,0.00130009,0.0009108773,0.00008013695,0.00011475,0.0001000509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3518536,"threshold_uncertainty_score":0.9996725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5092941805457951,"score_gpt":0.468741093657901,"score_spread":0.04055308688789411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}