{"id":"W4298087966","doi":"10.1111/joim.13571","title":"Cardiovascular effects of TMAO and other toxic metabolites of the intestinal microbiome","year":2022,"lang":"en","type":"letter","venue":"Journal of Internal Medicine","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; Western University","funders":"","keywords":"Trimethylamine N-oxide; Medicine; Microbiome; Carnitine; Internal medicine; Odds ratio; Choline; Creatine; Gastroenterology; Endocrinology; Stroke (engine); Physiology; Metabolite; Trimethylamine; Bioinformatics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006165236,0.000219531,0.0008260005,0.0001732461,0.0000298074,0.000004105288,0.0005198317,0.0002116048,0.00008446422],"category_scores_gemma":[0.0003443499,0.0001285116,0.000510439,0.000100566,0.0003152465,0.000002469125,0.0002078483,0.0009515044,2.741366e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002689469,"about_ca_system_score_gemma":0.0001351678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001314236,"about_ca_topic_score_gemma":0.000002568885,"domain_scores_codex":[0.9982884,0.00026604,0.0007335605,0.0001800536,0.0003468197,0.000185106],"domain_scores_gemma":[0.9982702,0.00008840857,0.001014876,0.0003537113,0.0002202262,0.00005264361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001041696,0.00002569292,0.0009260114,0.0008478701,0.001030985,0.00006962643,0.0001102228,0.000001467634,0.7921346,0.0000024449,0.2043673,0.0003795794],"study_design_scores_gemma":[0.00115031,0.001651139,0.001140393,0.00145959,0.0006213372,0.002456026,0.00004260464,4.068572e-7,0.193095,0.00002137813,0.7982495,0.0001122804],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7895539,0.1474135,0.0003614825,0.05786233,0.003801226,0.0004887792,0.00008362539,0.00000304959,0.0004321278],"genre_scores_gemma":[0.5999807,0.004917545,0.00112446,0.3748294,0.01548875,0.0000118897,0.00004371151,0.0002002952,0.003403321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5990396,"threshold_uncertainty_score":0.5240552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006878554383714027,"score_gpt":0.2427001037005198,"score_spread":0.2358215493168058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}