{"id":"W4298087966","doi":"10.1111/joim.13571","title":"Cardiovascular effects of TMAO and other toxic metabolites of the intestinal microbiome","year":2022,"lang":"en","type":"letter","venue":"Journal of Internal Medicine","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; Western University","funders":"","keywords":"Trimethylamine N-oxide; Medicine; Microbiome; Carnitine; Internal medicine; Odds ratio; Choline; Creatine; Gastroenterology; Endocrinology; Stroke (engine); Physiology; Metabolite; Trimethylamine; Bioinformatics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006630502,0.0005495941,0.0006998155,0.000813798,0.0003913174,0.001387945,0.0004045559,0.001407497,0.001753445],"category_scores_gemma":[0.001853279,0.0001872597,0.0003512105,0.0004718895,0.0003816354,0.0004428067,0.000562568,0.001280002,0.0003417735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002153548,"about_ca_system_score_gemma":0.0002150585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000381895,"about_ca_topic_score_gemma":0.0009575143,"domain_scores_codex":[0.9996051,0.0001472284,0.00003233897,0.00006283302,0.0001121949,0.00004034519],"domain_scores_gemma":[0.9987484,0.0005344533,0.0003686493,0.00005020226,0.0001491472,0.0001490787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008771498,0.0007390942,0.3211807,0.003131331,0.002467365,0.003016651,0.0007525504,0.0005686359,0.0183707,0.002462745,0.312486,0.3260527],"study_design_scores_gemma":[0.0005587875,0.003601473,0.6700059,0.001689255,0.002045169,0.007794617,0.0008012846,0.002524839,0.005659508,0.005150844,0.2999891,0.0001791799],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.1970664,0.6124606,0.003454926,0.109157,0.06921317,0.00006171875,0.002348174,0.0002120972,0.006026059],"genre_scores_gemma":[0.5410861,0.2273007,0.002909726,0.02985977,0.1924696,0.00008918226,0.001531811,0.0001092231,0.004643929],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.001753445,"threshold_uncertainty_score":0.005865872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006878554383714027,"score_gpt":0.2427001037005198,"score_spread":0.2358215493168058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}