{"id":"W4298109125","doi":"10.1210/clinem/dgac564","title":"Genetic Dissection of Primary Aldosteronism in a Patient With MEN1 and Ipsilateral Adrenocortical Carcinoma and Adenoma","year":2022,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Primary aldosteronism; Adrenocortical adenoma; MEN1; Adrenocortical carcinoma; Multiple endocrine neoplasia; Loss of heterozygosity; Adenoma; Aldosterone; Endocrinology; Internal medicine; Adrenal adenoma; Medicine; Hyperaldosteronism; Hypokalemia; Primary hyperparathyroidism; Biology; Allele; Endocrine system; Gene; Genetics; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004282426,0.00009901531,0.0006670412,0.000133618,0.00006293057,0.000003410158,0.00006603775,0.0000441545,0.000037632],"category_scores_gemma":[0.00009313881,0.00005696133,0.00006884128,0.00009052052,0.0002796752,0.00004276763,0.0001119235,0.0005900735,2.888983e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001854381,"about_ca_system_score_gemma":0.0001183246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002817038,"about_ca_topic_score_gemma":0.000007043705,"domain_scores_codex":[0.998096,0.0004318139,0.0008948633,0.0001208026,0.0002879305,0.0001686232],"domain_scores_gemma":[0.999032,0.0002709082,0.0003576332,0.0001310752,0.0000912765,0.0001171044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02460214,0.001201083,0.6532482,0.00006352756,0.0004580732,0.003131566,0.002552424,0.0001325963,0.01657117,0.001020143,0.0001384296,0.2968807],"study_design_scores_gemma":[0.004288822,0.002398723,0.9723292,0.00001674766,0.0003228557,0.01770257,0.0002454306,0.0001633195,0.0001756004,0.0002022109,0.002103113,0.00005140941],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990852,0.005592852,0.00001768731,0.003150646,0.0001386585,0.0001790343,0.000001486421,0.000003125571,0.00006450166],"genre_scores_gemma":[0.9979617,0.0007557816,0.0004267633,0.0007101019,0.0001040996,0.000003556475,8.075858e-7,0.000009704073,0.00002746934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.319081,"threshold_uncertainty_score":0.2563609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03040697246488195,"score_gpt":0.2993190765245487,"score_spread":0.2689121040596668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}