{"id":"W4298111265","doi":"10.1002/advs.202202590","title":"Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation","year":2022,"lang":"en","type":"article","venue":"Advanced Science","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Diabetic cardiomyopathy; Inflammation; In vivo; Pharmacology; Proinflammatory cytokine; In vitro; Gene silencing; Medicine; Chemistry; Cardiomyopathy; Heart failure; Immunology; Internal medicine; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008736918,0.0003119204,0.0001779661,0.0002043589,0.00009876535,0.000115114,0.0001549053,0.0002091456,0.0009436646],"category_scores_gemma":[0.0000432313,0.00006642691,0.0001741892,0.00006870087,0.0001651791,0.0001587538,0.0001193287,0.0004609474,0.0001212697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001142341,"about_ca_system_score_gemma":0.0001595545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002149035,"about_ca_topic_score_gemma":0.0004992568,"domain_scores_codex":[0.9999681,0.000007383739,0.000002604459,0.000004094452,0.000007429737,0.00001043382],"domain_scores_gemma":[0.9999747,0.000003124311,0.00000780921,0.000002171958,0.000003044945,0.000009045564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004272827,0.0001377037,0.0001121979,0.00006178927,0.000007100424,0.00002631015,0.000006284613,0.00007019199,0.9950961,0.00008910018,0.00003602765,0.003929772],"study_design_scores_gemma":[0.0001156701,0.002391113,0.006222962,0.00001406374,0.00003305015,0.0001293226,0.00003654615,0.001029818,0.9872706,0.0001102681,0.002640293,0.000006172299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940048,0.002341402,0.002016045,0.000141434,0.00002656782,0.00003183541,0.0000846422,0.00004541576,0.001307973],"genre_scores_gemma":[0.9942683,0.001870262,0.0018944,0.0001022822,0.00001322636,0.00002756584,0.0001520056,0.000006485378,0.001665365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009436646,"threshold_uncertainty_score":0.003156841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004400791095736652,"score_gpt":0.2084546114395402,"score_spread":0.2040538203438036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}