{"id":"W4298111265","doi":"10.1002/advs.202202590","title":"Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation","year":2022,"lang":"en","type":"article","venue":"Advanced Science","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Diabetic cardiomyopathy; Inflammation; In vivo; Pharmacology; Proinflammatory cytokine; In vitro; Gene silencing; Medicine; Chemistry; Cardiomyopathy; Heart failure; Immunology; Internal medicine; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007498598,0.0001266705,0.0001245351,0.00005324179,0.000713979,0.00005514803,0.0002179249,0.00002881723,0.000007034819],"category_scores_gemma":[0.0001679322,0.000124014,0.00003274465,0.00018967,0.0002119009,0.00003255399,0.0004023053,0.0001110981,0.000001704035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003851995,"about_ca_system_score_gemma":0.00006547278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001587542,"about_ca_topic_score_gemma":0.00000410942,"domain_scores_codex":[0.9986246,0.00007508387,0.0001652792,0.0004934857,0.000311356,0.0003301674],"domain_scores_gemma":[0.9995595,0.00002722921,0.0001165135,0.0001689371,0.00004457203,0.00008319875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001489612,0.00001324702,0.002737963,0.000006434191,0.000004195274,0.000002194706,0.00005445095,0.0003370379,0.9829607,0.00001939134,0.00003802698,0.01381146],"study_design_scores_gemma":[0.000216933,0.0001033175,0.001028963,0.00000882662,0.000005871102,0.00001757434,0.0003768977,0.0003345538,0.9937546,0.00003914241,0.003920152,0.0001931304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979379,0.0007227766,0.0005791852,0.0001347537,0.0001110903,0.0001426462,0.00005046048,0.00001712163,0.0003040977],"genre_scores_gemma":[0.9989002,0.00007180147,0.0007499097,0.00007234765,0.00005569317,0.00004232044,0.0000385118,0.000009606465,0.00005964879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01361833,"threshold_uncertainty_score":0.5491421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004400791095736652,"score_gpt":0.2084546114395402,"score_spread":0.2040538203438036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}