{"id":"W4298120913","doi":"10.1101/2022.09.28.509937","title":"Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital","funders":"","keywords":"Cancer; Small molecule; Cancer research; Medicine; Chemistry; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001222035,0.0002382392,0.0002070422,0.0001634762,0.00008514791,0.0002071496,0.0001226007,0.0001882943,0.001980603],"category_scores_gemma":[0.0000768664,0.00006971217,0.0001228412,0.00009478022,0.0001095808,0.0001094725,0.0001129401,0.0002941523,0.0003745345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157848,"about_ca_system_score_gemma":0.0001276255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001806579,"about_ca_topic_score_gemma":0.0003040814,"domain_scores_codex":[0.9999595,0.000007960833,0.000002927457,0.000006325164,0.00001302014,0.00001021422],"domain_scores_gemma":[0.9999669,0.000008232207,0.00000681191,0.000003079321,0.000005582474,0.000009405358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003310298,0.00009668832,0.0002187904,0.00008952378,0.000009403686,0.00007235877,0.00001131709,0.0005226328,0.985552,0.0006276302,0.0003042809,0.01216437],"study_design_scores_gemma":[0.0002167066,0.001716202,0.001969421,0.000008356444,0.00002319274,0.0002936601,0.000009077644,0.001142066,0.9850521,0.0001346677,0.009428898,0.000005713123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782436,0.008068654,0.003983139,0.0002648908,0.00007502569,0.0001402455,0.0005317616,0.0001801786,0.008512559],"genre_scores_gemma":[0.9895017,0.002118508,0.0040549,0.0001239307,0.00002166994,0.00007178223,0.0004690835,0.00001458626,0.003623755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001980603,"threshold_uncertainty_score":0.006625772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055826196935663,"score_gpt":0.2330534582874009,"score_spread":0.2124951963180443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}