{"id":"W4298122130","doi":"10.21203/rs.3.rs-2083312/v1","title":"Inhibition of the TRIM24 bromodomain reactivates latent HIV-1","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Provirus; Bromodomain; Long terminal repeat; Jurkat cells; Biology; Transcription (linguistics); Molecular biology; Virology; Retrovirus; Gene expression; Cell biology; T cell; Gene; Virus; Immunology; Genetics; Immune system; Epigenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652732,0.0002822024,0.000239902,0.0001649918,0.00009662002,0.0002283311,0.000310153,0.0001993199,0.001495673],"category_scores_gemma":[0.000103964,0.0001028851,0.0002795551,0.00008768584,0.0001508391,0.00009112873,0.0001433499,0.0005524358,0.0004213025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002161552,"about_ca_system_score_gemma":0.0001563907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004480439,"about_ca_topic_score_gemma":0.0005632006,"domain_scores_codex":[0.9998418,0.00002826268,0.00001756519,0.00001806518,0.00004193965,0.00005241411],"domain_scores_gemma":[0.9999259,0.00002037277,0.00001571746,0.00001139268,0.000006283576,0.0000203582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003381659,0.00009865288,0.0001309753,0.00006519407,0.00001489335,0.0000360134,0.00001071228,0.0001080569,0.9971246,0.00009394313,0.0001150034,0.001863877],"study_design_scores_gemma":[0.00005494139,0.0006933875,0.001405112,0.00000484712,0.00001801332,0.0001516745,0.00001026135,0.0006453945,0.9948725,0.00001730495,0.002123484,0.000003049371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946679,0.001930466,0.001316789,0.00006511802,0.00004597049,0.000040827,0.0003156929,0.0001157559,0.001501529],"genre_scores_gemma":[0.9964494,0.0006347649,0.0009414207,0.00006431995,0.00001468653,0.00003051538,0.000492027,0.00001083212,0.001362107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495673,"threshold_uncertainty_score":0.005003452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05304734522014262,"score_gpt":0.3516775505723966,"score_spread":0.298630205352254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}