{"id":"W4298124736","doi":"10.1093/biolre/ioac185","title":"Initial detachment of the mouse oocyte from the zona pellucida is mediated by metallopeptidase activity","year":2022,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Oocyte; Zona pellucida; Biology; Transmembrane protein; Cleavage (geology); Cell biology; Ovulation; Transmembrane domain; Extracellular; Epitope; Basigin; Biochemistry; Matrix metalloproteinase; Genetics; Antibody; Receptor; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001455797,0.0003046641,0.0003225303,0.0002084524,0.0001477004,0.0002861226,0.0001901753,0.0001914216,0.0008819913],"category_scores_gemma":[0.0001590564,0.0002097635,0.0004192886,0.0001371165,0.0001414053,0.0001453371,0.0002156848,0.0006953752,0.0004445981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003848858,"about_ca_system_score_gemma":0.0002403849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001174961,"about_ca_topic_score_gemma":0.001955647,"domain_scores_codex":[0.999833,0.00001208307,0.00001879003,0.0000336962,0.00005601118,0.00004631209],"domain_scores_gemma":[0.9999039,0.00001814577,0.0000318453,0.00001060954,0.0000133533,0.0000221508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005270865,0.000005585599,0.0001790528,0.00002142907,0.000003598408,0.00002404572,0.000008315648,0.00001307796,0.9991888,0.00001841093,0.00001853161,0.0004663255],"study_design_scores_gemma":[0.00001114032,0.0001379183,0.01061474,0.000007305888,0.00001104806,0.000147636,0.00002172304,0.0003788532,0.9862707,0.00001814949,0.002377786,0.000003043689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875121,0.004435175,0.004596416,0.0001393922,0.00002231073,0.00005829455,0.0007667437,0.0000961849,0.002373355],"genre_scores_gemma":[0.9837387,0.003280544,0.004793284,0.0001413369,0.00001346244,0.00008079488,0.001855833,0.00003311953,0.006062863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174961,"threshold_uncertainty_score":0.002950609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756199711213212,"score_gpt":0.2895690785942042,"score_spread":0.262007081482072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}