{"id":"W4298143422","doi":"10.32388/ewrlcz","title":"M-cell targeting acid-resistant oral vaccine delivery for immunization against Hepatitis B infection using cationic solid lipid nanoparticles","year":2022,"lang":"en","type":"preprint","venue":"","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"","keywords":"HBsAg; Hepatitis B; Antibody; Medicine; Hepatitis B virus; Immunization; Hepatitis B vaccine; Hepatitis; Virology; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000930537,0.0002443357,0.0001235183,0.0001313596,0.00008353475,0.0001294874,0.0001240734,0.0002768124,0.0004735509],"category_scores_gemma":[0.00006290647,0.0000786677,0.0001712741,0.00006441186,0.0001283885,0.000145005,0.0001617084,0.0002137171,0.0001754357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001611248,"about_ca_system_score_gemma":0.0001215575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002157158,"about_ca_topic_score_gemma":0.0003163953,"domain_scores_codex":[0.9999501,0.000008798354,0.000003475669,0.000009876193,0.00001742485,0.00001036303],"domain_scores_gemma":[0.9999745,0.000002685378,0.00001098939,0.000001630034,0.000005472959,0.000004753883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005154363,0.00002986786,0.0001130557,0.00008854779,0.000003383543,0.00003798719,0.000009180503,0.0001466965,0.9961804,0.0000983046,0.00005126009,0.003189863],"study_design_scores_gemma":[0.00002376756,0.0007776309,0.0005351428,0.00001133923,0.00001571601,0.0001744497,0.0000117902,0.001520584,0.9936737,0.00003261934,0.003218515,0.000004652706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833228,0.00382521,0.01056847,0.0001560363,0.00005463299,0.0000654321,0.00006308805,0.00008796501,0.001856265],"genre_scores_gemma":[0.9885256,0.001655253,0.007126685,0.00007169536,0.00001225137,0.00005302793,0.000101564,0.000009563793,0.002444422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004735509,"threshold_uncertainty_score":0.001584232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774547609347337,"score_gpt":0.2742186300274055,"score_spread":0.2564731539339322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}