{"id":"W4298145990","doi":"10.3390/ph15101208","title":"Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current INa by Lamotrigine; A Potential for Acquired Arrythmias","year":2022,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Heart and Stroke Foundation of Canada","keywords":"Lamotrigine; Brugada syndrome; Medicine; Sodium channel; Epilepsy; Effective refractory period; Blockade; Pharmacology; Anticonvulsant; Anesthesia; Refractory period; Internal medicine; Cardiology; Sodium; Chemistry; Psychiatry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001689154,0.0002584996,0.0002667954,0.0001314072,0.0001128349,0.0001396288,0.0001890659,0.0002161243,0.0007083846],"category_scores_gemma":[0.0001872846,0.00007368312,0.0001791417,0.00007861911,0.0002303112,0.0001617089,0.0001217256,0.0003706116,0.0001297237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002041884,"about_ca_system_score_gemma":0.0001798604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005093402,"about_ca_topic_score_gemma":0.0009723188,"domain_scores_codex":[0.9999068,0.00003003183,0.000009337828,0.000009967442,0.00001868698,0.00002525678],"domain_scores_gemma":[0.9999416,0.00001750164,0.00001706629,0.000007725367,0.00000650934,0.00000955301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001398297,0.00002498125,0.0003561594,0.00005418665,0.00001134513,0.0002403165,0.0000178046,0.00004106357,0.9968601,0.0002388949,0.0000349132,0.001980289],"study_design_scores_gemma":[0.00009171111,0.0012104,0.01972542,0.00001617455,0.00005660805,0.002065165,0.00005706607,0.001275327,0.973042,0.0002160703,0.002235301,0.000008605972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919924,0.003699525,0.002579427,0.0001491466,0.00002428117,0.00002470484,0.00007422949,0.00005154639,0.001404883],"genre_scores_gemma":[0.9979292,0.0008377479,0.0007291496,0.00004569732,0.000006861861,0.00001467382,0.0000401232,0.000004450075,0.0003919515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007083846,"threshold_uncertainty_score":0.002369761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02776077105855593,"score_gpt":0.3085163499273596,"score_spread":0.2807555788688036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}