{"id":"W4298145990","doi":"10.3390/ph15101208","title":"Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current INa by Lamotrigine; A Potential for Acquired Arrythmias","year":2022,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Heart and Stroke Foundation of Canada","keywords":"Lamotrigine; Brugada syndrome; Medicine; Sodium channel; Epilepsy; Effective refractory period; Blockade; Pharmacology; Anticonvulsant; Anesthesia; Refractory period; Internal medicine; Cardiology; Sodium; Chemistry; Psychiatry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003352388,0.0001312924,0.0001629753,0.00003003883,0.0002260038,0.00001090791,0.0001982115,0.00006351856,0.0001207634],"category_scores_gemma":[0.0000700957,0.0001109519,0.0002270221,0.0001298342,0.00005753711,0.000003382486,0.0002053693,0.0001107414,0.000002648243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002861986,"about_ca_system_score_gemma":0.00007747328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005026403,"about_ca_topic_score_gemma":2.44456e-7,"domain_scores_codex":[0.9988193,0.0001954372,0.0002451452,0.0002693449,0.000241764,0.0002290364],"domain_scores_gemma":[0.9994446,0.00002544692,0.0001198211,0.0002376952,0.00009372924,0.0000787034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000438664,0.0001969897,0.0002388096,0.00003789652,0.0000764145,2.717618e-7,0.00003314684,0.0004285347,0.9735575,0.0001897066,0.02051563,0.004286472],"study_design_scores_gemma":[0.001181444,0.0001270855,0.0003690276,0.000003095761,0.00007221919,0.000003705177,0.00003373085,0.001561722,0.7381516,0.0001185363,0.2582401,0.0001377832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907905,0.0009056906,0.001665481,0.00167341,0.003782047,0.0007162174,0.0003767244,0.00001833441,0.00007161103],"genre_scores_gemma":[0.9982141,0.0000744101,0.00003718163,0.0002320522,0.0006636191,0.0001759773,0.0002206802,0.0000188619,0.0003631158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2377245,"threshold_uncertainty_score":0.4524486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02776077105855593,"score_gpt":0.3085163499273596,"score_spread":0.2807555788688036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}