{"id":"W4298148582","doi":"10.1016/j.antiviral.2022.105427","title":"Genotypic correlates of resistance to the HIV-1 strand transfer integrase inhibitor cabotegravir","year":2022,"lang":"en","type":"article","venue":"Antiviral Research","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Dolutegravir; Integrase; Elvitegravir; Raltegravir; Virology; Integrase inhibitor; Rilpivirine; Drug resistance; Pharmacology; Human immunodeficiency virus (HIV); Genotype; Medicine; Drug; Biology; Viral load; Genetics; Antiretroviral therapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001187123,0.0001303235,0.0002450685,0.00025335,0.0003967509,0.00001936189,0.0002246322,0.00003787018,0.0002330969],"category_scores_gemma":[0.0001167082,0.00008396136,0.00009744498,0.0009343196,0.000156929,0.00004357217,0.0001134338,0.0006480961,0.0002337663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000145031,"about_ca_system_score_gemma":0.000317997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005818055,"about_ca_topic_score_gemma":0.0002242277,"domain_scores_codex":[0.9977189,0.0002822931,0.0002575765,0.0002912973,0.00102979,0.0004201878],"domain_scores_gemma":[0.9991478,0.0002521254,0.00001532193,0.0003379077,0.0001645824,0.00008226563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01719967,0.003785704,0.2389496,0.0005921974,0.001435615,0.001946552,0.04775903,0.0000300044,0.1651841,0.01261849,0.4492553,0.06124373],"study_design_scores_gemma":[0.01033754,0.002806867,0.1164053,0.0007074699,0.0003321308,0.00004982991,0.0221411,0.0001812176,0.3116108,0.001145279,0.53346,0.0008225642],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811396,0.0006770428,0.00008642937,0.01181491,0.00008508682,0.0009056745,0.000111434,0.00002041261,0.005159412],"genre_scores_gemma":[0.9212635,0.00007535337,0.0001334241,0.0000670895,0.00005276806,0.0001318751,0.00006162866,0.00002078007,0.07819356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1464267,"threshold_uncertainty_score":0.3423845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04051958899953462,"score_gpt":0.3356964735251377,"score_spread":0.295176884525603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}