{"id":"W4298225535","doi":"10.17615/q3bp-3c89","title":"An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1","year":2020,"lang":"en","type":"article","venue":"Figshare","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Eli Lilly Canada; University of North Carolina at Chapel Hill; Ontario Genomics; National Institutes of Health; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Methyltransferase; EZH2; Bioavailability; Lysine; Chemistry; Methylation; Pharmacology; Biochemistry; Biology; Amino acid; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00002739062,0.00008292657,0.00008917572,0.000007038645,0.00002921645,0.0000148758,0.0001468074,0.00008499289,0.001871505],"category_scores_gemma":[0.0002526998,0.00006184371,0.0000436648,0.00008174167,0.00001571682,0.000003246585,0.00006460404,0.00004885767,0.00001035036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001775516,"about_ca_system_score_gemma":0.00003922795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003388716,"about_ca_topic_score_gemma":0.000003512099,"domain_scores_codex":[0.9994761,0.0000330654,0.0001164444,0.0001992781,0.00008210952,0.00009297392],"domain_scores_gemma":[0.9996231,0.000008912363,0.00004121978,0.0001825809,0.00007453058,0.00006966212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000152754,0.00001881173,0.0004131682,0.00005872033,0.00001069428,2.744848e-7,0.00003581632,0.0000163506,0.9950314,0.000003901996,0.003265797,0.001129803],"study_design_scores_gemma":[0.0001636997,0.0001501006,0.001108021,0.00003877196,0.000008958154,5.135894e-7,0.0000093718,0.0001231938,0.9607422,0.00002081098,0.03755225,0.00008204572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616707,0.004037083,0.0001054629,0.0009702864,0.00002883527,0.0004328439,0.0319381,0.00002204504,0.0007946611],"genre_scores_gemma":[0.9896715,0.00003037572,0.0004719914,0.0002401435,0.000101179,0.00001630714,0.00941996,0.00001297417,0.00003557326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03428912,"threshold_uncertainty_score":0.9990409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.027362416657102,"score_gpt":0.2522993517947691,"score_spread":0.2249369351376671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}