{"id":"W4298225535","doi":"10.17615/q3bp-3c89","title":"An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1","year":2020,"lang":"en","type":"article","venue":"Figshare","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Eli Lilly Canada; University of North Carolina at Chapel Hill; Ontario Genomics; National Institutes of Health; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Methyltransferase; EZH2; Bioavailability; Lysine; Chemistry; Methylation; Pharmacology; Biochemistry; Biology; Amino acid; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001095745,0.0003978765,0.0001631533,0.0001699208,0.0001314918,0.0001510974,0.0003457598,0.0003975641,0.002002185],"category_scores_gemma":[0.0001013327,0.0001396931,0.0001864313,0.000143687,0.000138299,0.000187861,0.0001537944,0.0004602853,0.0004412119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003611198,"about_ca_system_score_gemma":0.0001995224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005799049,"about_ca_topic_score_gemma":0.0008612383,"domain_scores_codex":[0.9999214,0.00001311669,0.000004129507,0.00002137031,0.00001883213,0.00002102561],"domain_scores_gemma":[0.9999583,0.000006914571,0.00001291144,0.000005429007,0.000005882384,0.00001061356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002178317,0.0001060265,0.0001073251,0.00009769929,0.000009666024,0.0001283256,0.0000151689,0.0004080221,0.9913229,0.0005037132,0.0002803645,0.006802918],"study_design_scores_gemma":[0.00008900123,0.001805923,0.0005238363,0.000007356199,0.0000243022,0.0003171136,0.00001292526,0.0006373322,0.9838265,0.00008054767,0.01266755,0.000007663358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9488614,0.01063099,0.01767634,0.0005338907,0.0001326259,0.0003002189,0.001867245,0.0002219292,0.01977529],"genre_scores_gemma":[0.9823495,0.003706041,0.005602254,0.0001915379,0.00002097475,0.00009106533,0.0008650022,0.00001655318,0.007157066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002185,"threshold_uncertainty_score":0.006697953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.027362416657102,"score_gpt":0.2522993517947691,"score_spread":0.2249369351376671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}