{"id":"W4298274680","doi":"10.17615/y4eq-hw79","title":"Refining the UGT1A Haplotype Associated with Irinotecan-Induced Hematological Toxicity in Metastatic Colorectal Cancer Patients Treated with 5-Fluorouracil/Irinotecan-Based Regimens","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Université Laval","keywords":"Irinotecan; Fluorouracil; Colorectal cancer; Medicine; Toxicity; Oncology; Internal medicine; Chemotherapy; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003789481,0.0002625405,0.0003664101,0.0004572322,0.0002405855,0.0003295505,0.00016643,0.0002789794,0.0006946801],"category_scores_gemma":[0.001443796,0.0001571616,0.0003457989,0.0005464533,0.0002308353,0.0001225951,0.0001843698,0.000362793,0.0001430233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000264995,"about_ca_system_score_gemma":0.0002529064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003638741,"about_ca_topic_score_gemma":0.004250244,"domain_scores_codex":[0.9997361,0.0001070273,0.00002134219,0.00006769934,0.00003448727,0.00003340559],"domain_scores_gemma":[0.9994513,0.000169895,0.0002168746,0.0000484843,0.00003784852,0.00007550846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005179347,0.00002725738,0.9935703,0.000008334585,0.00005206861,0.0002364158,0.00007624027,0.0003266187,0.00232006,0.00002337827,0.00006332258,0.002777873],"study_design_scores_gemma":[0.00002440605,0.0002342106,0.9973955,0.000004558348,0.0000641192,0.0005638141,0.00004581151,0.00108532,0.0003450611,0.00003857683,0.0001938978,0.000004696896],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997179,0.00007447886,0.00007239109,0.00001419425,0.000001504259,0.000004025336,0.00002983753,0.00000135605,0.00008430775],"genre_scores_gemma":[0.9997608,0.00002282628,0.00009648866,0.00001101409,0.000003575193,0.000002210871,0.00006242991,0.000001192244,0.000039517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003638741,"threshold_uncertainty_score":0.00723511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02963030871400116,"score_gpt":0.2361260874116046,"score_spread":0.2064957786976034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}