{"id":"W4298274680","doi":"10.17615/y4eq-hw79","title":"Refining the UGT1A Haplotype Associated with Irinotecan-Induced Hematological Toxicity in Metastatic Colorectal Cancer Patients Treated with 5-Fluorouracil/Irinotecan-Based Regimens","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Université Laval","keywords":"Irinotecan; Fluorouracil; Colorectal cancer; Medicine; Toxicity; Oncology; Internal medicine; Chemotherapy; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008381667,0.0002765967,0.0003179318,0.00003206821,0.0001382613,0.00007711739,0.0002306242,0.0001331531,0.00003449021],"category_scores_gemma":[0.00008363305,0.0001692206,0.00005585794,0.000331739,0.0001426008,0.00001581723,0.0000733871,0.00021536,0.000001919266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004509034,"about_ca_system_score_gemma":0.0003362534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001689109,"about_ca_topic_score_gemma":0.001103052,"domain_scores_codex":[0.9985985,0.0001353214,0.0002271535,0.0004408963,0.0002355827,0.0003625807],"domain_scores_gemma":[0.9993638,0.00006427395,0.0001721719,0.0001958489,0.00009229978,0.000111545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01815891,0.002445458,0.2414918,0.000156397,0.002080342,0.0002275274,0.002459246,0.003171791,0.7109604,0.0100961,0.0009718009,0.007780233],"study_design_scores_gemma":[0.003710858,0.006168922,0.01285186,0.00008814309,0.0001348465,0.000003597554,0.0001659132,0.0008060359,0.9741238,0.0001785074,0.001248117,0.0005194294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974115,0.0001929542,0.0003306947,0.001379909,0.00003434207,0.0003110517,0.00006428921,0.00005506073,0.0002202313],"genre_scores_gemma":[0.9970394,0.00000537317,0.0005264699,0.00201977,0.00003557547,0.00011051,0.0001635623,0.00004349945,0.00005581514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2631634,"threshold_uncertainty_score":0.6900615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02963030871400116,"score_gpt":0.2361260874116046,"score_spread":0.2064957786976034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}