{"id":"W4298295205","doi":"10.17615/ne7w-yc76","title":"Polarity Inversion of Donor–Acceptor Cyclopropanes: Disubstituted δ-Lactones via Enantioselective Iridium Catalysis","year":2020,"lang":"en","type":"article","venue":"Figshare","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Science Foundation","keywords":"Enantioselective synthesis; Iridium; Chemistry; Catalysis; Polarity (international relations); Inversion (geology); Acceptor; Rhodium; Combinatorial chemistry; Stereochemistry; Organic chemistry; Physics; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00002171665,0.0002840601,0.0003833371,0.00007096658,0.0001263916,0.00003486637,0.0003861555,0.0002315441,0.1143576],"category_scores_gemma":[0.0007309875,0.000278794,0.0002238665,0.0004992377,0.00001795019,0.0003033492,0.0001613439,0.0003498703,0.001380766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515203,"about_ca_system_score_gemma":0.0001303479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001350547,"about_ca_topic_score_gemma":0.00003166679,"domain_scores_codex":[0.9984064,0.000026274,0.0003563769,0.0005161072,0.0003945298,0.0003002726],"domain_scores_gemma":[0.998681,0.00007811264,0.0003255352,0.0003686171,0.0003099784,0.0002367592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001083372,0.0001051385,0.0004984473,0.001374121,0.0001077239,0.00002182347,0.001126081,0.00001457861,0.9866461,0.000005039344,0.007722589,0.002270016],"study_design_scores_gemma":[0.0004491779,0.00003651163,0.0004109883,0.000261214,0.00006828477,0.000009734826,0.0005180115,0.0002926376,0.9792019,0.00001655959,0.01840844,0.0003265099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7113583,0.001301796,0.0001999133,0.001135046,0.0003456594,0.001216582,0.2599013,0.001869589,0.02267182],"genre_scores_gemma":[0.9314081,0.000007857037,0.0001188346,0.00007818374,0.0002246649,0.00005600846,0.06797185,0.00004323758,0.00009125809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2200498,"threshold_uncertainty_score":0.9999664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02718559994415271,"score_gpt":0.230455980317925,"score_spread":0.2032703803737723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}