{"id":"W4298326632","doi":"10.1016/j.jconrel.2022.09.048","title":"Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas","year":2022,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Brain Institute; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; Canada Research Chairs; National Institutes of Health; Branch Out Neurological Foundation; University of Toronto; Weston Brain Institute; Canadian Institutes of Health Research; Sunnybrook Research Institute; Foundation for the National Institutes of Health; Sunnybrook Foundation; Carlsbergfondet; ADC Foundation","keywords":"Gene delivery; Microbubbles; Biodistribution; Blood–brain barrier; Genetic enhancement; Parenchyma; Transduction (biophysics); Transgene; Adeno-associated virus; Biology; Medicine; Neuroscience; Pathology; In vivo; Vector (molecular biology); Gene; Central nervous system; Biophysics; Recombinant DNA; Ultrasound","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009798364,0.0006126127,0.0004177558,0.0005582375,0.000138377,0.0005837571,0.0002999219,0.0004069364,0.0005939782],"category_scores_gemma":[0.0007075692,0.0002545063,0.0003041673,0.000220382,0.0005812326,0.0006057659,0.0003631451,0.0004770262,0.0003309639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105948,"about_ca_system_score_gemma":0.0003449252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008256091,"about_ca_topic_score_gemma":0.0006423906,"domain_scores_codex":[0.9992194,0.0001658742,0.00008878497,0.0001558299,0.0002269525,0.0001432318],"domain_scores_gemma":[0.9993944,0.0002526497,0.0001180151,0.00005359493,0.0001138976,0.00006740323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000355571,0.00002006056,0.0002444241,0.00003673821,0.000006718044,0.00001208747,0.00001946049,0.00007707246,0.9976926,0.00008826454,0.00001017661,0.001757032],"study_design_scores_gemma":[0.000005388627,0.0006088517,0.00599192,0.00001228053,0.00003783804,0.0001176269,0.0000384055,0.0009215141,0.9913025,0.00009209338,0.0008625275,0.000009038127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758041,0.004294659,0.01684559,0.00008118944,0.00003050868,0.00009241387,0.0001421534,0.0001033664,0.002606019],"genre_scores_gemma":[0.985692,0.00345337,0.008750269,0.00006181864,0.00001773082,0.0001129466,0.0003622851,0.00004473788,0.001504843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009798364,"threshold_uncertainty_score":0.005181968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235343273144278,"score_gpt":0.2827820911364176,"score_spread":0.2704286584049748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}