{"id":"W4298326632","doi":"10.1016/j.jconrel.2022.09.048","title":"Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas","year":2022,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Brain Institute; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; Canada Research Chairs; National Institutes of Health; Branch Out Neurological Foundation; University of Toronto; Weston Brain Institute; Canadian Institutes of Health Research; Sunnybrook Research Institute; Foundation for the National Institutes of Health; Sunnybrook Foundation; Carlsbergfondet; ADC Foundation","keywords":"Gene delivery; Microbubbles; Biodistribution; Blood–brain barrier; Genetic enhancement; Parenchyma; Transduction (biophysics); Transgene; Adeno-associated virus; Biology; Medicine; Neuroscience; Pathology; In vivo; Vector (molecular biology); Gene; Central nervous system; Biophysics; Recombinant DNA; Ultrasound","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00114205,0.0001200113,0.000290571,0.0001184534,0.0001795595,0.0000267574,0.0001998767,0.00004567708,0.00003522484],"category_scores_gemma":[0.0007148226,0.00008385239,0.0001290086,0.0001046575,0.0000595431,0.000004119356,0.00007773194,0.0002253416,4.386735e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002442305,"about_ca_system_score_gemma":0.0001869692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001246005,"about_ca_topic_score_gemma":0.00002700132,"domain_scores_codex":[0.9985633,0.0004634788,0.0003171555,0.0001568793,0.0003246843,0.0001744768],"domain_scores_gemma":[0.9989099,0.0003808828,0.0002249447,0.0002059235,0.0001326659,0.0001457078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04573863,0.0001146377,0.0003038429,0.000005919442,0.0002767393,0.00002839596,0.00009731861,0.005958251,0.9410241,0.000006299454,0.001121668,0.005324158],"study_design_scores_gemma":[0.1019065,0.04669271,0.01091659,0.000117799,0.0004769223,0.002372422,0.001205812,0.002407359,0.8041422,0.0002099608,0.02866738,0.0008843106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925797,0.004253911,0.0001236646,0.002614092,0.00005753987,0.0003157164,0.00001971158,0.000001414099,0.00003422718],"genre_scores_gemma":[0.9976113,0.0002042285,0.0001076066,0.001682816,0.00018932,0.000006878018,0.000003404785,0.00001808013,0.0001763143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1368819,"threshold_uncertainty_score":0.3419401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235343273144278,"score_gpt":0.2827820911364176,"score_spread":0.2704286584049748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}