{"id":"W4298394429","doi":"10.1016/j.jtho.2022.07.1150","title":"There Is an Unmet Need for Another Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Inhibitor","year":2022,"lang":"en","type":"editorial","venue":"Journal of Thoracic Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Programmed cell death 1; Programmed cell death; Ligand (biochemistry); Programmed instruction; Apoptosis; Cancer research; Receptor; Internal medicine; Biochemistry; PD-L1; Cancer; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006333923,0.002651927,0.003369994,0.002211621,0.002555336,0.006818492,0.002654852,0.01935003,0.01133025],"category_scores_gemma":[0.018266,0.001176697,0.002676259,0.0008526829,0.00175238,0.003859523,0.001598775,0.02434938,0.008191993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002943089,"about_ca_system_score_gemma":0.002550322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008746302,"about_ca_topic_score_gemma":0.002593414,"domain_scores_codex":[0.9964468,0.0006593774,0.0004425141,0.0003707856,0.001758276,0.0003223097],"domain_scores_gemma":[0.98483,0.005539024,0.001303382,0.0003495339,0.004730148,0.003247805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009852245,0.00001717339,0.00004113852,0.0002683469,0.00003652043,0.0001548196,0.000009029946,0.00002794048,0.0001269618,0.0002307027,0.9892204,0.009768381],"study_design_scores_gemma":[0.0003086879,0.0001262003,0.000374379,0.0004784589,0.0001647781,0.0004671486,0.00004245327,0.0002412352,0.000241158,0.001327729,0.9961962,0.00003159719],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00006770132,0.007295211,0.0001380129,0.05621422,0.9349737,0.0000200131,0.00003991663,0.00005536587,0.001195855],"genre_scores_gemma":[0.0005210686,0.004013311,0.0001544936,0.04444558,0.9444603,0.00002396984,0.00003474196,0.00002698291,0.006319501],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.01935003,"threshold_uncertainty_score":0.03790343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03218937784012032,"score_gpt":0.3914572712840952,"score_spread":0.3592678934439749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}