{"id":"W4298894219","doi":"10.17615/x53z-fd51","title":"Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University of North Carolina at Chapel Hill; National Institutes of Health; Ministero dello Sviluppo Economico; Wellcome Trust; Eli Lilly Canada; GlaxoSmithKline; Pfizer; Eli Lilly and Company; Ontario Ministry of Economic Development and Innovation; V Foundation for Cancer Research","keywords":"Methyltransferase; Lysine; Substrate (aquarium); Chemistry; Biochemistry; Biology; Methylation; DNA; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001967182,0.0004806916,0.0004220785,0.0002703289,0.0001737173,0.0002213136,0.0007161109,0.0002958163,0.001402658],"category_scores_gemma":[0.0002205239,0.0001773837,0.00024516,0.0002376006,0.0001392053,0.0002034506,0.0002799165,0.0006383601,0.0004754055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004781297,"about_ca_system_score_gemma":0.000281934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00074176,"about_ca_topic_score_gemma":0.00231644,"domain_scores_codex":[0.999876,0.00001814651,0.000009495201,0.00002680249,0.00004033261,0.00002913586],"domain_scores_gemma":[0.999936,0.00001202897,0.00001042688,0.000005773042,0.00001646936,0.00001940498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004464426,0.000263031,0.0003567922,0.0002329843,0.0000500979,0.0001890599,0.00003979477,0.0009806186,0.9773138,0.00060349,0.001042969,0.01848097],"study_design_scores_gemma":[0.0002287024,0.001705686,0.001316679,0.00002066417,0.0000597656,0.0006502128,0.00001837682,0.005287594,0.9776759,0.0001132337,0.01290043,0.00002270236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9467406,0.01281943,0.02359883,0.0007466231,0.0002266488,0.0003733934,0.00182828,0.0007304936,0.01293579],"genre_scores_gemma":[0.9746191,0.006424516,0.01142754,0.0002444595,0.00002800413,0.000139584,0.001588676,0.00003933976,0.005488897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001402658,"threshold_uncertainty_score":0.004692316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137414604358348,"score_gpt":0.2111639037492814,"score_spread":0.1997897577056979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}