{"id":"W4298894219","doi":"10.17615/x53z-fd51","title":"Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University of North Carolina at Chapel Hill; National Institutes of Health; Ministero dello Sviluppo Economico; Wellcome Trust; Eli Lilly Canada; GlaxoSmithKline; Pfizer; Eli Lilly and Company; Ontario Ministry of Economic Development and Innovation; V Foundation for Cancer Research","keywords":"Methyltransferase; Lysine; Substrate (aquarium); Chemistry; Biochemistry; Biology; Methylation; DNA; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005403152,0.0001024385,0.0001553771,0.00001627604,0.00003514764,0.00001932371,0.0001433782,0.00007567996,0.000008093705],"category_scores_gemma":[0.0001114523,0.00007439347,0.0001080884,0.0001924398,0.0001778701,0.00001475072,0.00006600149,0.00006354676,5.510269e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002208844,"about_ca_system_score_gemma":0.0001327589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009849821,"about_ca_topic_score_gemma":0.00001003315,"domain_scores_codex":[0.9993166,0.00007876747,0.0002124003,0.0001779018,0.0001174753,0.00009680177],"domain_scores_gemma":[0.9996061,0.00003128216,0.00009099481,0.0001643967,0.00007563443,0.0000315963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000136158,0.00003659885,0.008743715,0.00004141183,0.00005742167,2.930222e-7,0.0003604843,0.00006884339,0.9734266,0.01695443,0.00007985808,0.00009414581],"study_design_scores_gemma":[0.0002841708,0.0002289874,0.006536197,0.0000123683,0.00002486044,1.747856e-7,0.0001655294,0.00001606296,0.9888215,0.00302463,0.0008032747,0.00008225664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933223,0.001165888,0.003082159,0.0004900441,0.00006452968,0.0001418299,0.0001014952,0.00000542958,0.001626339],"genre_scores_gemma":[0.9982901,0.00003808679,0.001270298,0.000118792,0.0001118329,0.000004069424,0.00005492421,0.00001271991,0.00009917712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01539485,"threshold_uncertainty_score":0.3033677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137414604358348,"score_gpt":0.2111639037492814,"score_spread":0.1997897577056979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}