{"id":"W4299125525","doi":"10.17615/2cks-1p06","title":"Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; University of North Carolina at Chapel Hill; National Institutes of Health","keywords":"Epigenetics; DNA methylation; Genetics; Inheritance (genetic algorithm); Biology; Histone; DNA; Computational biology; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009067952,0.0001143807,0.000105197,0.00007833675,0.0001508942,0.0002167847,0.0001719274,0.0001179769,0.001466442],"category_scores_gemma":[0.0001306936,0.00008112213,0.0001199398,0.00008142128,0.0001597403,0.0001894069,0.0003712033,0.0002136807,0.000322171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002823817,"about_ca_system_score_gemma":0.0001642703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004294639,"about_ca_topic_score_gemma":0.001114471,"domain_scores_codex":[0.9999199,0.0000073405,0.000005460759,0.0000234338,0.00002137977,0.00002247155],"domain_scores_gemma":[0.9999181,0.000009977209,0.00002667876,0.00001069321,0.000004845634,0.00002966989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003506834,0.000004177988,0.0004059066,0.000007543543,0.000002400549,0.00003051632,0.000006051368,0.00003969082,0.99839,0.0001770231,0.00001503292,0.0008865736],"study_design_scores_gemma":[0.000003224739,0.00004913664,0.007299969,0.000001842491,0.00000684297,0.0002505153,0.00002229675,0.0008262622,0.9898236,0.00007845352,0.001634666,0.000003080415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956372,0.0003209257,0.002926552,0.00003258622,0.000006161999,0.000004458218,0.00008534639,0.00005049412,0.0009363801],"genre_scores_gemma":[0.99788,0.0000641427,0.0008844098,0.00001135001,0.000001542753,0.000002705401,0.000110342,0.000008388525,0.001037229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466442,"threshold_uncertainty_score":0.00490576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03447933921633359,"score_gpt":0.265617186168392,"score_spread":0.2311378469520584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}