{"id":"W4299145386","doi":"10.17615/zccc-p637","title":"Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Robarts Research Institute; National Institutes of Health","keywords":"Endocytosis; Intracellular; Oligonucleotide; Cell biology; Receptor; Chemistry; Receptor-mediated endocytosis; G protein-coupled receptor; Biology; Biochemistry; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006575324,0.0001604612,0.0002881353,0.00004404626,0.000039661,0.00001634257,0.0001825594,0.0001253662,0.00001200084],"category_scores_gemma":[0.00009114245,0.00014204,0.000128905,0.0001843076,0.0002489483,0.00002034945,0.0001190051,0.000069479,0.000001390027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003131613,"about_ca_system_score_gemma":0.0000596279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002385269,"about_ca_topic_score_gemma":0.000003590895,"domain_scores_codex":[0.9990173,0.0000633157,0.0003245676,0.0003042251,0.0001314994,0.0001590983],"domain_scores_gemma":[0.9992781,0.00001055921,0.0002069842,0.0003045033,0.000107254,0.00009257197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003052726,0.00006950664,0.0001679339,0.0000548582,0.00008427571,0.000004322134,0.00007237654,0.000005802497,0.9960299,0.0005077212,0.0001342921,0.002563794],"study_design_scores_gemma":[0.0002306476,0.000630949,0.00003126772,0.00002357389,0.00003697695,0.000002670725,0.00009248354,0.0004243621,0.9962648,0.0005047614,0.001595749,0.0001617423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949467,0.0004990518,0.003931095,0.0002422249,0.00001667749,0.0001858273,0.00004002565,0.00005253934,0.00008587186],"genre_scores_gemma":[0.9080136,0.00004607659,0.09148508,0.0001592383,0.0001022447,0.000003847969,0.0001252109,0.00002132424,0.00004330984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08755399,"threshold_uncertainty_score":0.5792221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009974651010391801,"score_gpt":0.2137591170010139,"score_spread":0.2037844659906221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}