{"id":"W4299426051","doi":"","title":"Inhibition of a cathepsin L-like cysteine protease by a chimeric propeptide-derived inhibitor","year":2005,"lang":"en","type":"article","venue":"HAL (Le Centre pour la Communication Scientifique Directe)","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Cysteine protease; Cysteine; Cathepsin B; Protein precursor; Chemistry; Cathepsin S; Cathepsin L; Cathepsin C; Cathepsin E; Cathepsin; Cathepsin H; Protease inhibitor (pharmacology); Biochemistry; Cathepsin O; Enzyme; Biology; Virology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002324035,0.0003734881,0.0003193564,0.0001231759,0.0001094439,0.0003825858,0.0003102175,0.0004294685,0.001239164],"category_scores_gemma":[0.0001227992,0.0001056202,0.0003365789,0.0001209426,0.0001765073,0.0001858187,0.0001300399,0.0006760958,0.0005474749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004327837,"about_ca_system_score_gemma":0.0003006301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004955907,"about_ca_topic_score_gemma":0.0005001167,"domain_scores_codex":[0.999892,0.00001430332,0.000006858881,0.00002227174,0.000022235,0.00004227175],"domain_scores_gemma":[0.9999305,0.0000162924,0.00001694287,0.00000575627,0.00001087263,0.00001963015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002560179,0.00003499702,0.00004789346,0.00002980214,0.000007881118,0.00009348751,0.000005811255,0.0001810674,0.9978505,0.0001063449,0.00006698234,0.001319251],"study_design_scores_gemma":[0.00007793374,0.0005788744,0.0005124835,0.000004025749,0.0000222116,0.0004115237,0.000008294702,0.001600157,0.994162,0.00002680864,0.002590617,0.000004999796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822396,0.004842146,0.008221124,0.0002675537,0.0001090234,0.00008348895,0.0002976815,0.00009268773,0.003846654],"genre_scores_gemma":[0.9883758,0.001954199,0.004362704,0.00009304057,0.00002310882,0.00003856026,0.0005707474,0.00001443395,0.004567462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239164,"threshold_uncertainty_score":0.004145384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008686233785395549,"score_gpt":0.2208282539474555,"score_spread":0.21214202016206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}