{"id":"W4299526570","doi":"10.1136/annrheumdis-2022-eular.2518","title":"POS0306 EFFICACY AND SAFETY OF UPADACITINIB IN PATIENTS WITH ACTIVE ANKYLOSING SPONDYLITIS REFRACTORY TO BIOLOGIC THERAPY: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED PHASE 3 TRIAL","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Versus Arthritis; Pfizer","keywords":"Medicine; BASDAI; BASFI; Ankylosing spondylitis; Placebo; Clinical endpoint; Internal medicine; Randomized controlled trial; Physical therapy; Arthritis; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001711475,0.002112088,0.00420517,0.0003836844,0.000635111,0.001670372,0.001012198,0.002646812,0.006666436],"category_scores_gemma":[0.001529286,0.0007785856,0.002866031,0.0005694651,0.00162311,0.001744172,0.0003994063,0.004260795,0.001777224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007085999,"about_ca_system_score_gemma":0.0009870614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000617123,"about_ca_topic_score_gemma":0.001433982,"domain_scores_codex":[0.9993592,0.000309095,0.0000448198,0.0001146055,0.00005256066,0.0001198128],"domain_scores_gemma":[0.9991056,0.0002722977,0.000178736,0.00007262071,0.00006687205,0.0003038859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9803837,0.002826992,0.000492434,0.0006470609,0.001095725,0.00005267741,0.00004054915,0.0002800993,0.001777264,0.0001209886,0.001031014,0.01125154],"study_design_scores_gemma":[0.9608099,0.03610493,0.001388599,0.00003359546,0.0004709304,0.00005474158,0.00002042489,0.0003177797,0.0002246025,0.0001220537,0.0004328388,0.00001961687],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806687,0.009391286,0.0007342133,0.0009130237,0.0007845509,0.002252149,0.001799898,0.0002420604,0.003214009],"genre_scores_gemma":[0.9875264,0.003412627,0.000972382,0.001607953,0.0004286492,0.001966106,0.001867235,0.00003611578,0.002182602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006666436,"threshold_uncertainty_score":0.02230138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04194759857138649,"score_gpt":0.3306582363371709,"score_spread":0.2887106377657844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}